Serratia marcescens

The earliest commercially available filters were manufactured in two pore sizes 0.45 and 0.8 pm. The 0.45 pm-rated membranes were considered to be stefilizing-grade filters and were successfully used in the sterile filtration of pharmaceuticals and parenterals. The membrane filters were qualified using Serratia marcescens a standard bacterium, having dimensions of 0.6 x 1 pm. However, in the late 1960s it became apparent that the matrix of the 0.45 pm-rated filters could be penetrated by some pseudomonad-like organisms (1). For sterile filtration apphcations in the 1990s, 0.2 pm-rated membranes are the industry standard in the manufacture of sterile parenterals and pharmaceuticals. 

Salmonella heidelberg S. montevideo S. typhimurium S. enteritidis Sarcina lutea Serratia marcescens... 

Protease has also been demonstrated to exhibit antitumor activity. Intratumoral microinjection of proteases from Serratia marcescens into mice with sohd tumors resulted in necrosis and solubilization of the tumor mass (53). 

E Wolf, A Vassilev, Y Makmo, A Sail, Y Nakatam, SK Burley. Crystal structure of a GCN5-related N-acetyltransferase Serratia marcescens aminoglycoside 3-N-acetyltransferase. Cell 94 51-61, 1998. 

By separation Irom bacterial culture such as Escherichia coli, Serratia marcescens, Erwinia aroideae, Erwinia atroseptica, Erwinia carotovora. 

Serratia marcescens Isolate 8000 slaA 1,004/none — AB007125... 

Thus, Staphylococcus aureus produces a golden yellow pigment, Serratia marcescens a bright red pigment. There appears to be no valid function for these pigments but they may afford the cell some protection from the toxic effects of sunlight. 

Hospital isolates of Serratia marcescens may be highly resistant to ehlorhexidine, hexachlorophane liquid soaps and detergent creams. The outer membrane probably determines resistance to biocides. 

Acquired, non-plasmid-encoded resistance to biocides can result when bacteria are exposed to gradually increasing concentrations of a biocide. Examples are provided by highly QAC-resistant Serratia marcescens, and chlorhexidine-resistant Ps. mirabilis, Ps. aeruginosa md Ser. marcescens. 

The most common pathogens in bacterial keratitis are Pseudomonas (including Pseudomonas aeruginosa) and other gram-negative rods, staphylococci, and streptococci. If the keratitis is related to the use of contacts, Pseudomonas is the most common cause followed by Serratia marcescens. For hospitalized infants and adults on respirators, Pseudomonas is the most common.19... 

Other gram-negative organisms, such as Pseudomonas spp., have been noted to cause IE, especially in IVDUs and patients with prosthetic valves. Additionally, IE caused by Salmonella spp., Escherichia coli, Citrobacter spp., Klebsiella spp., Enterobacter spp., Serratia marcescens, Proteus spp. and Providencia spp. also has been reported.1... 

Serratia marcescens HasA/HasR Not characterized Haem Wandersman and... 

Serratia marcescens Unknown SfuA SfuB SfuC Iron(III) Braun et ah, 1998... 

Ciprofloxacin/ levofloxacin/ ceftriaxone,0 or cefotaxime0 T rimethoprim-sulfamethoxazole Serratia marcescens... 

Amoux, P., Haser, R., Izadi, N., Lecroisey, A., Delepierre, M., Wandersman, C. and Czjzek, M. (1999). The crystal structure of HasA, a hemophore secreted by Serratia marcescens, Nature Struct. Biol., 6, 516-520. 

Angerer, A., Gaisser, S. and Braun, V. (1990). Nucleotide sequences of the sfuA, sfuB, and sfuC genes of Serratia marcescens suggest a periplasmic-binding-protein-dependent iron transport mechanism, J. Bacteriol., 172, 572-578. 

Delepelaire, P., and Wandersman C. (1998). The SecB chaperone is involved in the secretion of the Serratia marcescens hasa protein through an ABC transporter. EMBO J. 17, 936-944. 

Serratia marcescens (a21)/host mediated assay Bacillus subtilis/spot test E. coli/spot test B. subtilis/spot test E. coli/spot test... 

The crystal structure of a pentamer of GlcNAc residues, representing the chitin polymer (poly-/l-(l-4)-GlcNAc), boimd to the chitinase enzyme ChiB from Serratia marcescens, revealed a narrow, timnel-like active site in the center of the TIM barrel fold [167]. Several conserved residues near the center of the site, which are important in catalysis, interact with the substrate via hydrogen bonds, while interactions farther from the center depend on van der Waals interactions. The sugar in the - 1 subsite adopts a boat conformation, presumably due to interactions with these critical active-site residues. 

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