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Solvents inert, water-soluble

Although benzenesulphonyl chloride has for simplicity been used in the above discussion, tolucne-/>- sulphonyl chloride, CHaCeH SO Cl, is more frequently used in the laboratory, owing to its much lower cost, the latter being due in turn to the fact that toluene-p-sulphonyl chloride is a by-product in the commercial preparation of saccharin. Toluene-p sulphonyl chloride is a crystalline substance, of m.p. 68° the finely powdered chloride will, however, usually react readily with amines in the Schotten-Baumann reaction it does not react so readily with alcohols, but the reaction may be promoted considerably by first dissolving the chloride in some inert water-soluble solvent such as acetone. [Pg.249]

The use of dimethylformamide (b.p. 153°) as a solvent and diluent often increases the yield materially. The vigour of the exothermic reaction which occurs with a relatively reactive aryl hahde is moderated and, furthermore, the dimethylformamide is easily removed from the reaction product since it is water soluble. Aryl hahdes which are inert under the usual Ullmann conditions do not react in the presence of dimethylformamide. [Pg.524]

Sohd, water-soluble a-hydroxycarboxyhc acid and oxaUc acid titanium complexes can be formed by reaction of the acid and a tetraaLkyl titanate in an inert solvent, such as acetone or heptane. The precipitated complex is filtered, rinsed with solvent, and dried to give an amorphous white soHd, which is water- and alcohol—water-soluble (81,82). [Pg.145]

These compounds are odourless, rather unstable compounds, and should be distilled under vacuum in an inert atmosphere. They are water-soluble but can be extracted from aqueous solution with a solvent such as diethyl ether. [Pg.69]

Inert solvents such as dimethyl ether [22], liquid sulfur dioxide or petroleum ether [23] were used to improve the quality of the sulfated alcohol or the reaction conditions. Solvents immiscible in water, such as petroleum ether [24], carbon tetrachloride [25], or butyl alcohol [26], as well as water-soluble sol-... [Pg.227]

To date most of the work which has been done with supercritical fluid extraction has concentrated on the extraction of analytes from solid matrices or liquids supported on an inert solid carrier matrix. The extraction of aqueous matrices presents particular problems [276-278]. The co-extraction of water causes problems with restrictor plugging, column deterioration, and phase separation if a nonpolar solvent is used for sample collection. Also, carbon dioxide isay have limited extraction efficiency for many water soluble compounds. [Pg.411]

For maximum efficiency, methylation should be a single-phase reaction and so those methods employing aqueous alkali are most suitable for water-soluble compounds and the Purdie method for non-polar compounds. A carbohydrate which is initially soluble in water e.g., starch, dextran) may be less soluble when partially methylated and for this reason an inert solvent e.g., acetone, dioxane, carbon tetrachloride) is often introduced during the later stages of a methylation with dimethyl sulfate. It is interesting to note that methyl a-D-glucopyranoside forms a trithallium derivative which is insoluble in water and consequently the introduction of more than three methoxyl groups by the Menzies method... [Pg.160]

The selectivity of the ozone reaction in pure solvent or water-solvent systems is known from early studies conducted by chemists under analytical and preparative aspects (Bailey, 1958). Inert solvents (e. g. pentane, carbon tetrachloride) provide an opportunity to produce and study oxidation products of the ozonolysis, such as ozonides at low temperatures (Criegee, 1975). Only in the last two decades have ozonation techniques been developed and studied that utilize the higher ozone solubility, enhanced mass transfer rates, higher reaction rates etc. to be found in water-solvent systems. [Pg.154]

J-Butyl Ether. -Butyl ether is prepared by dehydration of -butyl alcohol by sulfuric acid or by catalytic dehydration over ferric chloride, copper sulfate, silica, or alumina at high temperatures. It is an important solvent for Grignard reagents and other reactions that require an anhydrous, inert medium. /7-Butyl ether is also an excellent extracting agent for use with aqueous systems owing to its very low water-solubility. [Pg.429]

Assays are often performed in an aqueous medium with water as the solvent. Most drugs are organic molecules with poor water solubility. To improve solubility or at least evenly disperse the compound throughout the assay well, compounds are commonly dissolved in dimethyl sulfoxide (DMSO). DMSO has several attractive properties. DMSO dissolves organic compounds well, has a low vapor pressure to limit evaporation, and is fairly inert. Furthermore, DMSO freezes around 18 °C. A solution of a compound in DMSO can be easily frozen for long-term storage. Because high concentrations of DMSO may affect the reliability of an assay, compound solutions must be prepared such that, when mixed in the assay, the final DMSO concentration is 1% or less. [Pg.22]

A factor common to each of these processes is that substances must past through one or more cellular membranes. Small, lipophilic molecules are the substances that pass most easily through such membranes. The key connection here is that the chemical properties that are desirable in solvents require them to be composed of small, lipophilic molecules. Thus, solvents are some of the most easily absorbed and distributed in the body. However, the most easily excreted substances are those that are water soluble. Thus, the solvents relative inertness results in storage in the body rather than in biotransformation, which in turn prevents elimination from the body. Prolonged exposure to solvents, therefore, can result in the accumulation of a toxic concentration of that substance. This example is one of many in science in which properties that are desirable for one purpose can be detrimental for others. [Pg.101]

This material has several advantages it is chemically inert, symmetrical, volatile (bp 27°C), and soluble in most organic solvents it gives a single, intense, sharp, absorption peak, and its protons are more shielded than almost all organic protons. When water or deuterium oxide is the solvent, TMS can be used as an external reference in a concentric capillary or the methyl protons of the water-soluble sodium 2, 2-dimethyl-2-silapentane-5-sulfonate (DSS), (CH3)3SiCH2CH2CH2S03Na, are used as an internal reference (0.015 ppm). [Pg.138]

Recently, a ruthenium-catalysed oxidation in water was published by d Alessandro et al. [34]. Water can be regarded as an environmentally friendly solvent which, because it is inert, reduces the risk of explosions. The oxidation of cyclohexane directly to adipic acid was performed using ruthenium catalysts bearing water-soluble phthalocyanine ligands RuPcS (where PcS is tetra-sodium 2,3-tetrasulfophthalocyaninato) with KHSOs (Eq. 4). However we note that very low TONs were observed and the use of KHSOs as a primary oxidant is not viable for industrial-scale oxidations. [Pg.287]


See other pages where Solvents inert, water-soluble is mentioned: [Pg.265]    [Pg.60]    [Pg.245]    [Pg.25]    [Pg.213]    [Pg.120]    [Pg.34]    [Pg.439]    [Pg.311]    [Pg.18]    [Pg.18]    [Pg.220]    [Pg.605]    [Pg.276]    [Pg.324]    [Pg.175]    [Pg.230]    [Pg.36]    [Pg.276]    [Pg.60]    [Pg.708]    [Pg.60]    [Pg.362]    [Pg.404]    [Pg.439]    [Pg.310]    [Pg.353]    [Pg.304]    [Pg.62]    [Pg.98]    [Pg.58]    [Pg.5]    [Pg.112]   
See also in sourсe #XX -- [ Pg.19 , Pg.176 ]




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Inert solvents

Solubility solvents

Solvent inert solvents

Solvent, water

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