Solubility improvements

It is not recommended to take saw patmdto as a tea because the active constituentsare not water soluble. Improvement can be seen after 1 to 3 months of therapy. It is usually recommended that the herb be taken for 6 months followed by evaluation by a primary health care provider. 

Polymer solubility improves with increasing temperature polymer molecules in solution uncoil to a greater degree, and hence occupy larger volume and elute earlier from the GPC column. 

Detergents 2003 Volatility-solubility improvers Odor inhibitors or masking agents 343... 

Boatright and Hettiarachchy (1995) reported that solubility improvement in soy protein resulted from preventing its oxidation by adding antioxidants and corresponded with the increase in total protein surface hydrophobicity as determined by the SDS binding method (see Basic Protocol 2). This hydrophobicity was not the total protein hydrophobicity but is similar to the exposable hydrophobicity, Se, which is Sq measured in the presence of SDS (Townsend and Nakai, 1983). This change in the exposure of hydrophobic sites in protein molecules is dependent on the concentration of SDS used in the analysis. One of the advantages of the SDS binding method is that there is no need for an expensive spectrofluorometer. 

In general, then, the larger the discrepancy in ion size, the greater would be the solubility improvement. In the case of the large cation and large anion, the salt is probably poorly soluble, and a decrease in the size of the drug s counterion would be the direction leading to improved solubility. 

Mask reactive species to improve its therapeutic index Improve solubility Improve oral absorption... 

Methyl Increased lipophilic character Decreased water solubility. Increased lipid solubility. Improves ease of absorption but makes its release from biological membranes more difficult. Can lead to changes in the nature and rate of metabolism. Larger alkyl groups will have similar effects. 

S. Katayama, J. Shima, and H. Saeki, Solubility improvement of shellfish muscle protein by reaction with glucose and its soluble state in low-ionic-strength medium, J. Agric. Food Chem., 2002, 50, 4327-4332. 

Low sensitivity Low-global separation Solubilization problems Basic, hydrophobic proteins poorly soluble Improved sensitivity Low-global separation Solubilization problems Basic, hydrophobic proteins poorly soluble Protein ID difficult Low-global separation Limited mass range Prefractionation needed for better resolution Limited validated Ab s Cross-reactivity epitopes Semi-quantitative Protein-protein interactions may mask epitope sites... 

Hypericin 1 is very poorly soluble in many solvents. In view of its potent antiviral activity especially against HIV this is a major drawback as it restricts the bioavailability of this compound. Researchers have tried many ways to find better soluble forms of hypericin 1 in both water and organic sovents e.g. by preparing esters, ethers, salts, amino acid complexes [26] or by preparation of ion pairs [27]. Other possibilities of solubility improvement included the introduction of polar functions such as carboxylic acid groups [28]. 

Chemistry control of aqueous solubility is poor because, except for a few very specific exceptions, chemistry SAR is blunt. In this respect, control of solubility like that of permeability is poor. Solubility due to excessive lipophilicity improves only gradually as the lipophilicity is moved in the desired downward direction. Trying to decrease lipophilicity by incorporating polar functionality may or may not work. The potential solubility improvement attendant on introdu-... 

For the fraction containing the LSD, conversion to LSD tartrate must be done to make it water soluble, improve its keeping characteristics, and to allow crystallization. Tartaric acid has the ability to react with two molecules of LSD. Use, then, of a 50% excess of tartaric acid dictates the use of about 1 gram of tartaric acid to 3 grams of LSD. The three grams of LSD would be expected from a well-done batch out of a total 3.5 LSD/iso-LSD mix. 

Table 1.2 indicates that in a series of copolymers, solubility improves with a decrease in the fraction of perylenecarboximide nnits. A copolymer containing 20 mol% perylenecarboximide rings exhibits good solubility in chloroform, whereas a copolymer bearing 80 mol% of these... 

High water solubility, improved antimicrobial activity 25,79,... 

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