Serum triglyceride levels

While the fibric acid derivatives have antihyperlipidemic effects, their use varies depending on the drug. For example, Clofibrate (Atromid-S) and gemfibrozil (Lopid) are used to treat individuals with very high serum triglyceride levels who present a risk of abdominal pain and pancreatitis and who do not experience a response to diet modifications. Clofibrate is not used for the treatment of other types of hyperlipidemia and is not thought to be effective for prevention of coronary heart disease. Fenofibrate (Tricor) is used as adjunctive treatment for the reduction of LDL, total cholesterol, and triglycerides in patients with hyperlipidemia. 

Niacin is used as adjunctive therapy for the treatment of very high serum triglyceride levels in patients who present a risk of pancreatitis (inflammation of the pancreas) and who do not experience an adequate response to dietary control. 

Monitor serum triglyceride levels with prolonged infusions... 

Tibric acid (10), interestingly, has the m-carboxysulfonamido functionality but its activity is expressed, instead, as suppression of serum triglyceride levels. In its reported preparation, chloro-sulfonic acid treatment converts 2-chlorobenzoic acid to chlorosulfonate 9, which readily forms the hypolipidemic agent tibric acid (10) on reaction with... 

Increases in serum lipids and glucose appear to be transient and of little clinical importance. /J- Blockers increase serum triglyceride levels and decrease high-density lipoprotein cholesterol levels slightly. /1-Blockers with -blocking properties (carvedilol and labetalol) do not affect serum lipid concentrations. 

Fig. 8.4 Distribution of serum triglyceride levels from cord blood of 282 babies.

With high serum triglyceride levels and moderately elevated cholesterol. 

Blood chemistry and serum hepatic enzyme levels, CD4-I- cell count and blood glucose, HIV RNA, and serum triglyceride levels... 

Pravastatin is indicated as an adjunct to diet in patients with primary hypercholesterolemia, mixed dyslipidemia, elevated serum triglyceride levels and primary dysbetalipoproteinemia who do not respond adequately to diet. 

It is cholesterol lowering agent with antioxidant property. It is only 1/10 absorbed when given orally. It reduces the serum cholesterol levels without reduction in serum triglycerides level and also reduces the HDL levels. It has no effect on VLDL and triglyceride levels. 

Male Fischer 344 rats (body weight, 100-150 g) were fed 0.5-4% di(2-ethyl-hexyl) phthalate in the diet for one or four weeks and male Swiss Webster mice (20-30 g) were fed 2 or 4% di(2-ethylhexyl) phthalate in the diet for one or four weeks (Reddy etal., 1976). Di(2-ethylhexyl) phthalate increased relative liver weights and markedly induced hepatic carnitine acetyltransferase activity in both species (up to 25-fold in rats and 10-fold in mice). Some increase in hepatic catalase activity (approximately two-fold) was observed and subjective (non-morphometric) ultra-structural examination revealed marked peroxisome proliferation. This study also demonstrated that di(2-ethylhexyl) phthalate was a hypolipidaemic agent, as serum triglyceride levels were reduced to one seventh of control values in rats and one third of control values in mice. 

Liu C-L, Yang T-L. Sequential changes in serum triglyceride levels during adjuvant tamoxifen therapy in breast cancer patients and the effect of dose reduction. Breast Cancer Res Treat 2003 79 11-16. 

A similar inhibitory effect of EM-800 was observed on serum triglyceride levels. The daily administration of 25 jig of EM-800 for 9 months... 

Lee NA, Reasner CA. 1994. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care 17(12) 1449-1452. 

While mean triglyceride levels were higher for the UF and UF+Mn periods than for the lower fat periods, the difference was only significant for the manganese-supplemented (MF+Mn versus UF+Mn, P<0.005) period. No effect of dietary manganese on serum triglyceride levels was seen. 

A decrease in serum cholesterol levels results in a decrease not only in the lipid content but also in the size of experimentally induced atherosclerotic lesions. Evidence of this association in man has been demonstrated by coronary angiography. " Human femoral atherosclerosis regressed in response to diet and/or drug therapy (clofibrate, NA, or clofibrate in combination with neomycin). "> The degree of retardation of atherosclerosis was directly correlated with the decrease in serum cholesterol levels. " Regression in patients with Type IV hyperlipoproteinemia was also associated with the decrease in serum triglyceride levels however, no such correlation was found in another study. ... 

Serum enzyme (AST, ALT, LDH, AP) and bilirubin levels were within normal limits in 16 workers exposed to PCBs (type not reported) primarily via dermal contact with used transformer oil containing 600,000 ppm PCBs or secondary contact with contaminated clothes or shoes (Brandt-Rauf and Niman 1988). No correlation between serum triglyceride levels and serum PCB levels was found. Physical examinations showed no dermal or other abnormalities consistent with PCB exposure, but it is not specifically mentioned if the examinations looked for liver enlargement. Serum PCB concentrations in the study group were low (generally <10 ppb) in comparison to other occupational studies. 

Feeding of D-fructose or sucrose produces hyperlipemia (increase in serum triglyceride levels) in man159,274-283 and laboratory animals.284-292 Induced hyperlipemia may cause atherosclerosis.293 Thus, it is important to understand the mechanism by which D-fructose induces increased levels of serum triglyceride. 

FIGURE 34 Clofibrate lowers serum triglyceride levels by accelerating catabolism of very-low-density lipoproteins. 

Serum triglyceride levels in chickens infected with all subgroup C viruses were increased. The greatest change was induced by RAV-7 with a mean of 1500 mg/dl after 45 days compared with a range of 68.2-90.5 mg/dl in uninfected chickens. Cholesterol levels decreased initially followed by a significant increase, 45 days posthatching. Marked hyperlipidemia was present only in RAV-7-infected chickens. 

Increases in serum cholesterol levels were observed in two studies where rats were fed either 2.8 or 10 mg zinc/kg/day as zinc acetate for 2-7 months (Katya-Katya et al. 1984 Klevay and Hyg 1973). Other studies have shown no effect on total cholesterol, HDL cholesterol, or serum triglyceride levels in rats ingesting 3 or 25 mg zinc/kg/day of unspecified zinc compounds (Fischer et al. 1980 Woo et al. 1983). 

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