Hypolipidaemic agents

Male Fischer 344 rats (body weight, 100-150 g) were fed 0.5-4% di(2-ethyl-hexyl) phthalate in the diet for one or four weeks and male Swiss Webster mice (20-30 g) were fed 2 or 4% di(2-ethylhexyl) phthalate in the diet for one or four weeks (Reddy etal., 1976). Di(2-ethylhexyl) phthalate increased relative liver weights and markedly induced hepatic carnitine acetyltransferase activity in both species (up to 25-fold in rats and 10-fold in mice). Some increase in hepatic catalase activity (approximately two-fold) was observed and subjective (non-morphometric) ultra-structural examination revealed marked peroxisome proliferation. This study also demonstrated that di(2-ethylhexyl) phthalate was a hypolipidaemic agent, as serum triglyceride levels were reduced to one seventh of control values in rats and one third of control values in mice. 

Price SC, Chescoe D, Grasso P, et al. 1988a. Alterations in the thyroids of rats treated for long periods with di-(2-cthylhexyl) phthalate or with hypolipidaemic agents. Toxicol Lett 40 37-46. 

Curcumin has been proved to be an effective hypolipidaemic agent (Babu and Srinivasan, 1997). One study validated the role of dietary curcumin in maintaining healthy serum cholesterol levels in diabetic rats. Employing a high-cholesterol diet for the diabetic rats, curcumin exhibited a lowering of cholesterol and phospholipid in treated animals as compared with curcumin-free controls. Liver cholesterol, triglycerides and phospholipid elevated under diabetic conditions were lowered by dietary curcumin. Curcumin induces a... 

Pyridine derivatives are important as pharmaceuticals. Nicotinic acid derivatives are used as vasodilators, anticoagulants and hypolipidaemic agents. Derivatives of isonicotinic acid (pyridine-4-carboxylic acid) such as isoniazide 215 and ethionamide 216 are used as tuberculostatics, and of 2-benzylpyridine in the form of pheniramine 217 as antihistamine. 

It is used as a hypolipidaemic agent in conjunction with dietary modification. 

Nityanand, S., J.S. Srivastava, and O.P. Asthana. 1989. Clinical trials with gugulipid. A new hypolipidaemic agent. /. Assoc. Physicians India 37(5) 323-328. 

Ester with 2- 4 chlorophenoxy)-2-methylpropanoic acid [55902-94-8]. Sitofibrate, INN. Hypolipidaemic agent. 

Pharmacology/toxlcll pharmacological doses (of 2-4 g daily) have been used in trials as a hypolipidaemic agent... 

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