Wound treatment

There are two ways of wound treatment under dry or wet conditions. In the former gauze is applied to the skin, the latter calls for the use of hydrogels. 

The demonstration of the potential of this stable and obviously excellently tolerated compound has inspired a great number of scientists to develop PFCLs as special tools for medical applications and to introduce therapies using the outstanding behaviours of PFCLs, like the well-known concepts of complete and partial liquid ventilation [4], oxygen support of the skin, wound treatment [5], artificial tears [6], and ocular endotamponade media [1], to name only a few. Until now, the mouse submersed in PFCLs is often used as an eye-catcher for the demonstration of the biocompatibility of PFCLs even in cases where the topic of the presentation is not reflected by this experiment. 

Excipients bring properties to formulations that facilitate the conversion of the API to a medicine. These functional properties will depend on the particular formulation. For parenteral products, open wound treatments, and ocular treatments, there are specific additional requirements concerning impurities, microbiological load, and endotoxins. However, excipients intended for nonsterile applications very often function, because they are not single chemical compounds. There are other functional or concomitant components frequently present, which are necessary to achieve the required performance (functionality) of the excipient in use. These should be considered separately from any impurities, process residues, or foreign substances that may be present. (In some applications, certain components that have traditionally been considered to be impurities or residues, may actually be concomitant components.) It is important to understand that these other components, whatever their source, may also interact with the API or other excipients. 

Mertz, P.M., Davis, S.C., Cazzangi, A.L., Drosou, A., Eaglstein, W.H., University of Miami School of Medicine and Narang, U., Closure Medical Corporation Raleigh, NC, Microbial Proliferation and Barrier Protection of 2-Octyl Cyanoacrylate Derived Wound Treatment Films, July 2001 (Research Report). 

In addition to its usage in the treatment of respiratory ailments, coltsfoot is also used to treat diarrhea, purify the blood, stimulate metabolism, cause diuresis and swelling, and topically as a wound treatment. Today, products containing coltsfoot are promoted as antihistamines, decongestants, and expectorants. 

Ancient uses of daffodil components included systemic administration for hysterical affections, emesis, dysentery, chronic bronchial congestion, ague, and spasms. In addition, a plaster made of the roots was applied topically to dissolve hard swellings. An extract of the bulbs was also applied to open wounds, presumably as a crude anti-inflammatory agent, although wound treatment with Narcissus bulb extract could produce staggering, numbness of the whole nervous system, and paralysis of the heart. ... 

One aim of modern wound treatment with new materials is the reduction of infection and the normalization of healing. In veterinary medicine, experience with such optimized materials are limited and conclusions are contradictory. Some investigations have been carried out on the leg of horses, but - in comparison with other animals or kinds of wounds - these show different healing processes characteristics [127-133]. The majority of clinical trials introduce modern wound-treatment materials applied in human medicine to veterinary practice. These studies show positive results [134-136]. 

BC is a good material not only for wound treatment and other fields of veterinary medicine, but also as a scaffold material for cell cultivation in tissue engineering [156,157]. On such scaffolds the fzmb has cultivated the following cell types successfully human osteoblasts, human osteogenic sarcoma cells (SAOS-2), equine osteoblast lines and chondrocytes, and mesenchymal stem cells. 

In practice, further important aspects of BC are the focus of interest, concerning cooling of overtaxed muscles and particularly wound treatment of animals such as horses, sheep, cows, cats, and dogs. Extremely highly infected wounds are frequent in dogs after car crashes or similar accidents [143]. Furthermore, treatment of badly healing and permanent wounds, e.g., ulcers, and in the clinical and home-care sector both for human and veterinary medicine, as well as specific applications in tissue engineering will be major future developments. 

Figure 9 The coordination of silver in silver sulfadiazine, the topical agent for bums and wound treatment the Ag-Ag dimeric unit stabilized by two head-to-tail bridging sulfadiazine ligands bound via pyrimidinyl and sulfamido nitrogen donor atoms only the nitrogen and sulfur donor atoms of the third sulfadiazine ligands are shown. SULPMS from the Cambridge Crystallography Database...

Betony Betonica officinalis With others in wound treatment... 

St Johns Wort Hypericum perforatum With others, wound treatments... 

Indications Antisepsis, Preoperative skin preparation, Wound treatment, vaginal douch Category Antiseptic Half-life N/A... 

Modern wound treatment is a highly scientific and skilled speciality. In general, surgical dressings fall into three categories ... 

These investigations have shown that the alcoholic extract and esculin obtained from Fraxinus ornus bark exercise moderate skin regenerating effects, no toxicity or local irritation being observed. The experimental results are in line with the antimicrobial properties of the extract and its constituents, and with the use of the bark in the traditional medicine for wound treatment and against inflammation. 

Gilchrist T, Martin AM. Wound treatment with Sorbsan—an alginate fibre dressing. Biomaterials 1983 4 317-320. 

AR Johnson, AC White, B McAnalley. Comparison of common topical agents for wound treatment cytotoxicity for human fibroblasts in culture. Wounds 1 186-192,... 

RI Burks. Povidone-iodine solution in wound treatment. Phys Ther 78 212-218,... 

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