Mouse dominance

Shukla Y, Taneja P (2002) Mutagenic potential of cypermethrin in mouse dominant lethal assay. J Environ Pathol Toxicol Oncol 21 259-265... 

Mouse Dominant lethal mutation - Litton Bionetics 1980... 

Litton Bionetics. 1980. Mutagenicity evaluation of M-hexane in the mouse dominant lethal assay Final report. Unpublished study by Litton Bionetics Inc., Kensington MD. Prepared for the American Petroleum Institute, Washington DC. EPA-FYI-AX-0183-0231. 

Mammalian cells CD-I mouse (dominant lethal assay) Swiss mouse (dominant lethal assay) Domi nant Domi nant 1ethal 1ethal. a, b a, c Arnold et al. 1977 Epstein et al. 1972... 

API. 1981. Mutagenicity evaluation of diesel fuel in the mouse dominant lethal assay. Washington, DC American Petroleum Institute. 

Negative results were reported in various mutagenic assays including the Ames Salmonella assay (with or without microsomal activation), sister chromatid exchange assay in mouse lymphoma cells, mouse bone marrow cyto-genic analysis, and mouse dominant lethal assay ... 

Mouse Dominant lethal (ip) — Deknudt and Leonard 1982 Nickel acetate... 

Barnett, L.B., Lovell, D.P.., Felton, C.F., Gibson, B.J., Cobb, R.R., Sharpe, D.S., Shelby, M.D. Lewis, S.E. (1992) Ethylene dibromide negative results with the mouse dominant lethal asssay and the electrophoretic specific locus test. Mutat. Res., 282, 127-133... 

Group C of Table 9-3 consists of some special cases that had inconsistent, ambiguous, or puzzling results. Ethanol has been negative in all tests except the mouse dominant-lethal test. It should be tested further. More dose-response data and supplemental tests might be especially helpful. 

Captan had one ambiguous result and one positive result in the two Tier I tests used. It was also positive in the, mouse dominant-lethal test. Because results in the Drosophila test were negative, captan is a doubtful mutagen that requires more testing. 

Dominant lethal tests are usually conducted in mice or rats. The mouse dominant lethal test is more economical, but the rat dominant lethal test is more informative, as corpora lutea may be accurately enumerated in pregnant female rats, but not in mice, to assess preimplantation loss. Although dominant lethal tests may be performed with treated females, the tests are commonly performed with treated males in order to identify stages sensitive to mutation induction during germ cell development because the knowledge of stage sensitivity is important for risk evaluation. In a typical dominant lethal test, males... 

Of the 19 pesticides grouped in Table II, all were negative in five Phase I bioassays and the Phase 2 bioassays performed. These compounds included insecticides (I), fungicides (F), and herbicides (H). Malath ion, parathion, pentachloronitrobenzene (PCNB), and phorate were also negative for heritable chromosomal effects in the mouse dominant lethal test. The six compounds grouped in Table III that were positive in three or more bioassays were acephate, captan, demeton, folpet, monocrotophos, and trichlorfon. Positive results were seen for demeton in all in vitro tests in Phase 1 and Phase 2. Folpet and captan were positive in all Phase 1 and all Phase 2 in vitro assays except the test for unscheduled DNA synthesis in WI-38 cells. Trichlorfon was positive in all Phase 1 and Phase 2 in vitro tests, with the exclusion of relative toxicity tests with E coli and subtiI is. 

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