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Saccharomyces cerevisiae mutation assay

Saccharomyces cerevisiae, reverse mutation Saccharomyces pombe, forward mutation Saccharomyces cerevisiae DEL assay, and iCR recombination Drosophila melanogaster, crossing-over/recombination Drosophila melanogaster, somatic mutation... [Pg.105]

The mutagenic potential of diisopropyl methylphosphonate was investigated using the Ames assay. The compound was obtained from two different sources and tested on Salmonella typhimurium strains TA-1535, TA-1537, TA-1538, TA-98, and TA-100, both with and without S-9 activation. The compound did not demonstrate mutagenic activity in any of the assays (Hart 1980). Diisopropyl methylphosphonate was also negative for gene mutation in Saccharomyces cerevisiae (Hart 1980). [Pg.94]

Salmonella typhimurium (reverse mutation) Escherichia coli (forward mutation, DNA modification) Saccharomyces cerevisia (reverse mutation) Bacillus subtilis (rec assay) Gene mutation or DNA modification Bruce and Heddle 1979 Dunkel et al. 1984 Fukunaga et al. 1982 Kharab and Singh 1985 Nestmann et al. 1979 Nishioka 1975 Rosenkranz and Poirier 1979 Simmon 1979b... [Pg.303]

Saccharomyces cerevisiae gene mutation assay OECD... [Pg.79]

Brusick and Matheson (1976) reported that 1,1-dimethylhydrazine failed to increase reversions in Salmonella typhimurium or Saccharomyces cerevisiae gene mutation assays with or without metabolic activation. A concentration-related response was observed in the mouse lymphoma assay (with activation). Dominant lethal tests were negative. [Pg.188]

Jagannath DR. 1981. Mutagenic evaluation of S276 in the Saccharomyces cerevisiae reverse mutation induction assay. Study No. T4003065. Litton Bionetics Inc., Kensington, MD. [Pg.189]

Genetic Toxicology Saccharomyces cerevisiae. Gene Mutation Assay (Original Guideline, adopted 23 October 1986)... [Pg.21]

Genetic toxicology Saccharomyces cerevisiae, gene mutation assay 1986... [Pg.152]

The Saccharomyces cerevisiae gene mutation assay OECD TG 480 EU Annex V B.15... [Pg.154]

Positive results from the Saccharomyces cerevisiae gene mutation assay indicate that a substance induces point mutations by base pair substitution or frameshift in the genome. Base pair substimtion and frameshift is explained under the in vivo test. [Pg.162]

Zimmermatm, E.K., Heinisch, J. Scheel, I. (1985) Tests for the induction of mitotic aneu-ploidy in the yeast Saccharomyces cerevisiae strain D61.M. In Ashby, J., de Serres, E.J., Draper, M., Ishidate, M., Jr, Margolin, B.H., Matter, B.E. Shelby, M.D., eds. Progress in Mutation Research, Volume 5, Evaluation of Short-Term Tests for Carcinogens. Report of the International Programme on Chemical Safety s Collaborative Study on in vitro assays, Amsterdam, Elsevier Science, pp. 235-242... [Pg.322]

Bacillus subtilis H17 rec MA5 recT, DNA damage assay Saccharomyces cerevisiae JDl, gene conversion Drosophila melanogaster, sex-linked recessive lethal mutation Unscheduled DNA synthesis, primary rat hepatocytes in vitro Sister chromatid exchange, Chinese hamster ovary CHO cells in vitro... [Pg.394]

In the mouse host-mediated assay, diepoxybutane induced mutation in. S typhimurium TA1530 but did not induce mitotic recombination in Saccharomyces cerevisiae D3. [Pg.192]

Brooks, T.M., Gonzalez. L.P.. Calvert. R. Parry, J.M. (1985) The induction of mitotic gene conversion in the yeast Saccharomyces cerevisiae strain JDl. Prog. Mutat. Res.. 5, 225-228 Budavari, S., ed. (1996) The Merck Index. 12th Ed., Whitehouse Station, NJ, Merck Co, p. 287 Carere, A., Conti, G, Conti. L. Crebelli, R. (1985) Assays in Aspergillus nidulans for the... [Pg.396]

Mehta, R.D. von Borstel, R.C. (1985) Tests for genetic activity in the yeast Saccharomyces cerevisiae using strains D7-144, XV185-14c and RM52. Prog. Mutat. Res., 5, 271-284 Myhr, B., Bowers, L. Caspary, W.J. (1985) Assays for the induction of gene mutations at the... [Pg.398]

Mitchell, I.deG. Gilbert, PJ. (1982) Activity of 4-chloromethylbiphenyl, 4-hydroxymethyl-biphenyl and benzyl chloride in assays for gene conversion and petite induction in Saccharomyces cerevisiae strain D4. Mutat. Res., 100, 169-172... [Pg.475]

There is conflicting evidence concerning the mutagenicity of 1,2-dimethylhydrazine to bacteria. In a single study, it induced recombination in Saccharomyces cerevisiae. In vitro, 1,2-dimcthylhydrazine formed DNA adducts in human bronchial cells, provoked unscheduled DNA synthesis in rat hepatocytes and induced gene mutation in mammalian cells. It gave positive results in rodents in microbial host-mediated assays. [Pg.975]

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See also in sourсe #XX -- [ Pg.256 ]



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