Genetic activity

Garrett NE, Stack HE, Waters MD. 1986. Evaluation of the genetic activity profiles of 65 pesticides. MutatRes 168 301-326. [Pg.209]

Bronzetti G, Zeiger E, Frezza D. 1978. Genetic activity of trichloroethylene in yeast. J Environ Pathol Toxicol 1 411-418. [Pg.256]

Callen DF, Wolf CR, Philpot RM. 1980. Cytochrome P-450-mediated genetic activity and cytotoxicity of seven halogenated aliphatic hydrocarbons in Saccharomyces cerevisiae. Mutat Res 77 55-63. [Pg.256]

Ahlberg J, Ramel C, Wachtmeister CA. 1972. Organolead compounds shown to be genetically active. Ambio 1 29-31. [Pg.484]

Garrett NE, Stack HF, Gross MR, et al. 1984. An analysis of the spectra of genetic activity produced by known or suspected human carcinogens. Mutat Res 134 89-111. [Pg.108]

Matheson, D., D.Brusick, and D.Jagannath. 1978. Genetic activity of 1,1-dimethylhydrazine and methylhydrazine in a battery of in vitro and in vivo assays. Mutat. Res. 53 93-94. [Pg.159]

Choice of Tissue. The next choice is that of source tissue. Preparations derived from liver are the most useful, as this tissue is a rich source of mixed-function oxygenases capable of converting procarcinogens to genetically active electrophiles. However,... [Pg.193]

PXR has been demonstrated to act as an LCA sensor and plays an essential role in detoxification of cholestatic bile acids [11,61]. Studies in different animal models showed that activation of PXR protected against severe liver damage induced by LCA. Pretreatment of wild-type mice, but not the PXR-null mice, with PCN reduced the toxic effects of LCA. Moreover, genetic activation of PXR by expressing the activated... [Pg.302]

Waters MD, Claxton, LD, Stack HF, et al. 1990. Genetic activity profiles in the testing and evaluation of chemical mixtures. Teratogenesis Carcinog Mutagen 10(2) 147-164. [Pg.147]

ZIMMERMAN, F. K. Detection of Genetically Active Chemicals Using Various Yeast Systems , ibid., p. 209. [Pg.99]

Regulation of genetic activity and gene function are now the central points of interest. Genetic diseases are rarely caused by the damage of one single gene. [Pg.23]

RNA Ribonucleic adds are macromolecules found in all cells in both the nucleus and the cytoplasm. Messenger RNA (mRNA) is an exact reflection of the genetically active DNA, carrying the... [Pg.139]

Fahmy, M.J. Fahmy, O.G (1984) Genetic activity of the carcinogen A-nitrosodiethanol-amine (NDELA) on unstable mutant alleles of the white locus in Drosophila melanogaster. Teratog. Carcinog. Mutag., 4, 437-447... [Pg.432]

Inge-Vechtomov, S.G., Pavlov, Y.I., Noskov, V.N., Repnevskaya, M.V, Aarpova, T.S., Khromov-Borisov, N.N., Chekuolene, J. Chitavichus, D. (1985) Tests for genetic activity in the yeast Saccharomyces cerevisiac. study of forward and reverse mutation, mitotic recombination and illegitimate mating induction. Prog. Mutat. Res., 5, 243-255... [Pg.98]

Kramers, P.G., Mout, H.C., Bissumbhar, B. Mulder, C.R. (1991) Inhalation exposure in Drosophila mutagenesis assays experiments with aliphatic halogenated hydrocarbons, with emphasis on the genetic activity profile of 1,2-dichloroethane. Mutat. Res., 252, 17-33... [Pg.306]

Budavari, S., ed. (1996) The Merck Index, 12th Ed., Whitehouse Station, NJ, Merck Co., p. 297 Callen, D.F., Wolf, C.R. Philpot, R.M. (1980) Cytochrome P-450 mediated genetic activity and cytotoxicity of seven halogenated aliphatic hydrocarbons in Saccharomyces cerevisiae. [Pg.424]

Fahmy, M.J. Fahmy, O.G. (1982) Genetic activities of 4-chloromethylbiphenyl, the 4-hydroxy derivative and benzyl chloride in the soma and germ line of Drosophila melanogaster. Mutat. Res., 100, 339-344... [Pg.473]

Rosenkranz, H.S. (1975) Genetic activity of l,2-dibromo-3-chloropropane, a widely-used fumigant. Bull, environ. Contam. Toxicol., 14, 8-12... [Pg.498]

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