Diisopropyl methylphosphonate

A peer review panel was assembled for diisopropyl methylphosphonate. The panel consisted of the following members ... [Pg.9]

These experts collectively have knowledge of diisopropyl methylphosphonate s physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, human and animal exposure, and quantification of risk to humans. All reviewers were selected in conformity with the conditions for peer review specified in Section 104(I)(13) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended. [Pg.9]

WHAT HAPPENS TO DIISOPROPYL METHYLPHOSPHONATE WHEN IT ENTERS THE ENVIRONMENT ... [Pg.11]

IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXPOSED TO DIISOPROPYL METHYLPHOSPHONATE ... [Pg.11]

Biomarkers Used to Identify or Quantify Exposure to Diisopropyl Methylphosphonate... [Pg.12]

Existing Information on Health Effects of Diisopropyl Methylphosphonate 5-1 Frequency of NPL Sites with Diisopropyl Methylphosphonate Contamination... [Pg.15]

Levels of Significant Exposure to Diisopropyl Methylphosphonate - Oral 2-2 Levels of Significant Exposure to Diisopropyl Methylphosphonate - Dermal 2-3 Genotoxicity of Diisopropyl Methylphosphonate In Vivo... [Pg.17]

Analytical Methods for Determining Diisopropyl Methylphosphonate in Biological Samples... [Pg.17]

This public health statement tells you about diisopropyl methylphosphonate and the effects of exposure. [Pg.19]

The Environmental Protection Agency (EPA) identifies the most serious hazardous waste sites in the nation. These sites make up the National Priorities List (NPL) and are the sites targeted for long-term federal clean-up. Diisopropyl methylphosphonate has been found in at least 2 of the 1,416 current or former NPL sites. However, it s unknown how many NPL sites have been evaluated for this substance. This is important because exposure to this substance may harm you and because these sites may be sources of exposure. [Pg.19]

If you are exposed to diisopropyl methylphosphonate, many factors determine whether you ll be harmed. These factors include the dose (how much), the duration (how long), and how you come in contact with it. You must also consider the other chemicals you re exposed to and your age, sex, diet, family traits, lifestyle, and state of health. [Pg.19]

Diisopropyl methylphosphonate is a colorless liquid at normal temperatures. It is also known as methyl-,bis-(l-methyl-ethyl)ester, phosphonic acid, and methyl-diisopropyl ester. [Pg.19]

Diisopropyl methylphosphonate, or DIMP, is a chemical by-product resulting from the manufacture and detoxification of GB (also called Sarin), a nerve gas that the Army produced... [Pg.19]

Exposure of the general population to diisopropyl methylphosphonate is expected to be rare and even then in small amounts. Only people living near a site where DIMP is found (such as RMA) may be exposed to this substance. [Pg.21]

Please refer to Chapter 5 for more information on how you might be exposed to diisopropyl methylphosphonate. [Pg.21]

Diisopropyl methylphosphonate may enter your body after drinking water contaminated with it or it may enter through your skin. You could be exposed to diisopropyl methylphosphonate if you drink water that contains the chemical near the RMA. Exposure of the general population to diisopropyl methylphosphonate is not likely to occur. Studies in animals show that diisopropyl methylphosphonate enters the bloodstream relatively quickly following oral exposure. Animal... [Pg.21]

Little is known about the human health effects of diisopropyl methylphosphonate. Skin rashes and other signs of irritation have been reported in some people who handled dead animals near a pond containing diisopropyl methylphosphonate and other chemicals, but it is not known which substances caused these effects. [Pg.22]

Drinking large amounts of diisopropyl methylphosphonate kills animals. The amount needed to cause death in humans is not known for sure. Animal studies have shown no evidence that drinking or eating diisopropyl methylphosphonate causes fertility problems or birth defects. Animal studies have shown that eating diisopropyl methylphosphonate can affect some liver enzymes (indicating a response by the liver). However, test animals showed no liver disease. While most animal studies have shown only minimal toxic effects below a certain level of... [Pg.22]

See Chapter 2 for more information about the health effects of diisopropyl methylphosphonate. [Pg.23]

Once inside the body, diisopropyl methylphosphonate is rapidly converted to isopropyl methyl-phosphonic acid (IMPA), which is rapidly cleared from the blood. Laboratory tests can determine the amount of IMP A in the blood or urine. However, because IMPA leaves the body rapidly, these tests are useful only for recent exposure. It is helpful for your doctor to know whether there are other chemicals to which you have been exposed. See Chapters 2 and 6 for more information. [Pg.23]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

See also in sourсe #XX -- [ Pg.677 ]

See also in sourсe #XX -- [ Pg.685 , Pg.1229 ]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

See also in sourсe #XX -- [ Pg.100 ]

See also in sourсe #XX -- [ Pg.31 , Pg.33 ]

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