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Saccharomyces cerevisiae Yeast Mutation Assays

The use of yeast cells as a eukaryotic complement to the Ames test led to the development of several protocols for the detection of mutation, gene conversion and recombination. The formal introduction of methods [23] followed by much development work from Zimmermarm s laboratory led to large systematic studies [24, 25] and OECD guidelines for the test battery (OECD 480, 481). However the assays are now rarely used, at least in part because of concerns over low sensitivity, thought to reflect limited permeability of the cell wall. [Pg.256]

Saccharomyces cerevisiae gene mutation assay Yeast Gene mutations in yeast B15/TG480... [Pg.446]

Zimmermatm, E.K., Heinisch, J. Scheel, I. (1985) Tests for the induction of mitotic aneu-ploidy in the yeast Saccharomyces cerevisiae strain D61.M. In Ashby, J., de Serres, E.J., Draper, M., Ishidate, M., Jr, Margolin, B.H., Matter, B.E. Shelby, M.D., eds. Progress in Mutation Research, Volume 5, Evaluation of Short-Term Tests for Carcinogens. Report of the International Programme on Chemical Safety s Collaborative Study on in vitro assays, Amsterdam, Elsevier Science, pp. 235-242... [Pg.322]

Brooks, T.M., Gonzalez. L.P.. Calvert. R. Parry, J.M. (1985) The induction of mitotic gene conversion in the yeast Saccharomyces cerevisiae strain JDl. Prog. Mutat. Res.. 5, 225-228 Budavari, S., ed. (1996) The Merck Index. 12th Ed., Whitehouse Station, NJ, Merck Co, p. 287 Carere, A., Conti, G, Conti. L. Crebelli, R. (1985) Assays in Aspergillus nidulans for the... [Pg.396]

Mehta, R.D. von Borstel, R.C. (1985) Tests for genetic activity in the yeast Saccharomyces cerevisiae using strains D7-144, XV185-14c and RM52. Prog. Mutat. Res., 5, 271-284 Myhr, B., Bowers, L. Caspary, W.J. (1985) Assays for the induction of gene mutations at the... [Pg.398]

An analysis of mutable sites in the DNA-binding domain of human p53 has been performed using a yeast functional assay. This assay is based on the expression of human p53 introduced into Saccharomyces cerevisiae containing a p53-dependent reporter gene. Random mutagenesis has revealed that mutation at 542 sites in a 1079-bp fragment could inactivate p53 DNA binding. This number is remarkably close to the number of observed sites at... [Pg.107]

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