Saccharomyces pombe

Studies in yeasts (Saccharomyces cerevisiae, Schizo-saccharomyces pombe), slime mould (,Dictyostelium discoideum), worm (Caenorhabditis elegans), fly (Drosophila melanogaster) and mammalian systems have all contributed to our understanding of TOR signalling. 

Human Set9 is a 50 kDa H3 methyltransferase that methylates Lys-4 of H3. The enzyme methylated free H3 but not H3 in chromatin substrates. There is evidence that Set9 may stimulate activated transcription [198]. Set9 has the SET domain but lacks the cysteine-rich (pre-SET and post-SET) domains. Disruption of Saccharomyces cerevisiae and Saccharomyces pombe Setl obliterates H3 methyl Lys-4 [199]. Thus this SET domain containing protein appears to be a H3 Lys-4 methyltransferase, catalyzing both di- and tri-methylation of H3 Lys-4 [155]. However, studies with recombinant Setl failed to show histone methyltransferase activity. It has been suggested that other associated proteins may be required for the Setl to be catalytically active [139,200]. Indeed, Setl is associated with several... 

Saccharomyces cerevisiae, reverse mutation Saccharomyces pombe, forward mutation Saccharomyces cerevisiae DEL assay, and iCR recombination Drosophila melanogaster, crossing-over/recombination Drosophila melanogaster, somatic mutation... 

Williams, P., Keshavarz-Moore, E., and Dunnil, P. 1996. Production of cadmium sulphide microcrystallites in batch cultivation by Saccharomyces pombe. Jou rnal of Biotechnology, 48 259-67. 

An interesting development in this field is the recent report by Dameron et al. (88) of the biosynthesis of quantum-sized CdS crystals in the yeast cells Candida glabrata and Schizo saccharomyces pombe. Exposed to Cd ions these cells synthesize certain peptides with an enhanced sulfide production. Small CdS crystals are formed inside the cells. These crystallize in the rock salt structure (and not in the thermodynamically stable hexagonal configuration). The organism controls particle nucleation and growth, so that uniformly sized CdS particles of about 20 A are formed. They show pronounced quantum-size effects. This is the first example of the biosynthesis of quantum-sized semiconductor crystallites. It constitutes a metabolic route for the detoxification of Cd " -infected living cells (see also 89). 

Mediator Subunits in S , cerevisiae and Their Homologues in Saccharomyces pombe and Human Cells... 

Kin28 kinase. The molecular basis for Mediator s ability to stimulate CTD phosphorylation is unknown. However, the observation that Saccharomyces pombe Mediator is unable to stimulate TFIIH derived from S. cerevisiae indicates that specific interactions are formed between Mediator and TFIIH (Spahr et al., 2000). 

New name Homo sapiens Drosophila melanogaster Caenorhablitis elegans (Previous name) Ce New name Saccharomyces cerevisiae Saccharomyces pombe... 

Clr4 Saccharomyces pombe Su(var) H3K9 55,918 8.64 Gene silencing, heterochromatin formation... 

During the re-synthesis of the cell-wall region by protoplasts of Schizo-saccharomyces pombe, synthesis of /8-D-glucan has been found to precede synthesis of (1 3)-a-D-glucan. D-Glucans, referred to as elicitors, but so... 

Fig. 7. Inhibition by cytoplasmic protein inhibitors of the incorporation of pH] leucine in Schizo-saccharomyces pombe 972h . S. pombe 972h was inoculated at a density of 10 cells per ml into a medium containing 1% glucose,...

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