Role of lipids

Smith, M. T., Thor, H., and Orrenius, S. (1983). The role of lipid peroxidation in the toxicity of foreign compounds to liver cells, Biochem. Pharmacol., 32, 763-764. 

Cullis PR, Fenske DB, Fiope MJ Physical properties and functional roles of lipids in membranes. In Biochemistry of Lipids, Lipoproteins and Membranes. Vance DE, Vance JE (editors). Elsevier, 1996. 

BROWN M s and goldstein j l (1990) Scavenging for receptors Nature 343, 508-9. ESTERBAUER H, GEBiKi J, PUHL H and JURGENS G (1992) The role of lipid peroxidation and antioxidants in oxidative modification of LDL Free Radical Biology and Medicine 13, 341-90. 

The chemical adducts formed by reaction of aldehydes with lysine residues form highly immunogenic epitopes, and antibodies have been prepared specific for malondialdehyde- and 4-hydroxynonenal-conjugated LDL (Gonen et al., 1987 Yla-Herttuala et al., 1989 Jurgens et al., 1990). These antibodies cross-react with material in atherosclerotic lesions but not normal tissue, thus supporting the central role of lipid peroxidation in the patho nesis of atherosclerosis (Yla-Herttuala et al., 1989, 1991). 

Esterbauer, H., Gebicki, J. Puhl, H. and Jurgens, G. (1992), The role of lipid peroxidation and antioxidants in oxidative modification of low density lipoprotein. Free Rad. Biol. Med. 13, 341-390. 

Bacon, B.R. and Britton, R.S. (1989). Hepatic injury in chronic iron overload role of lipid peroxidation. Chem. Biol. Interact. 70, 183-226. 

Biasi, F., Albano, E., Chiarpotto, E., Corongju, F.P., Pron-zato, M.A., Marinari, U. M., Parola, M., Dianzani, M.U. and Poli, G. (1991). Invivo and in vitro evidence concerning the role of lipid peroxidation in the mechanism of hepatocyte death due to carbon tetrachloride. Cell Biochem. Function 9, 111-118. 

Seo HS, Lombardi DM, Polinsky P, et al. Peripheral vascular stenosis in apolipoprotein E-deficient mice—potential roles of lipid deposition, medial atrophy, and adventitial inflammation. Arterioscler Thromb Vase Biol 1997 17(12) 3593—3601. 

WN Charman, CJH Porter, S Mithani, JB Dressman. Physicochemical and physiological mechanisms for the effects of food on drug absorption the role of lipids and pH. J Pharm Sci 86 269-282, 1997. 

The role of lipids on absorption has been extensively reviewed by Porter and Charman [29, 30]. The influences are diverse and include effects on luminal drug solubility, altering the metabolic and barrier function of the intestinal wall, stimulating lymphatic transport and a reduction in gastric transit, thereby increasing the time available for dissolution. 

Silver EH, Szabo S. 1982. Possible role of lipid peroxidation in the actions of acrylonitrile on the adrenals, liver and gastrointestinal tract. Res Commun Chem Pathol Pharmacol 36 33-43. 

In biological membranes, the class of fully saturated PC lipids is just one of many. Indeed, variations in the lipid architecture are frequently encountered. There are variations with respect to the head-group structure as well as variations in the tail architecture. For example, in the tails, single or multiple unsaturated bonds are very common. There is relatively little knowledge about the role of lipid unsaturation in biomembranes. There are relatively few MD simulations on bilayers composed of lipids with unsaturated bonds. Nevertheless, single unsaturation as well as multiple unsaturated chains have been of some interest. For a recent review see reference [102], We will now present a selection of the results. We will also take this opportunity to compare the results from the MD simulations with those from the SCF calculations. 

Ianora A, Boersma M, Casotti R, Fontana A, Harder J, Hoffmann F, Pavia H, Potin P, Poulet SA, Toth G (2006) New trends in marine chemical ecology. Estuaries Coasts 29 531-551 Irigoien X (2004) Some ideas about the role of lipids in the life cycle of Calarms finmarchicus. J Plankton Res 26 259-263... 

Albano E, Poli G, Tomasi A, et al. 1984. Toxicity of 1,2-dibromoethane in isolated hepatocytes Role of lipid peroxidation. Chem Biol Interact 50 255-266. 

Zhang Y, Anchordoquy T. The role of lipid charge density in the serum stability of cationic lipid/DNA complexes. Biochim Biophys Acta 2004 1663 143. 

A brief overview about the fundamental principles of the pathogenesis of skeletal muscle insulin resistance and its contribution to the development of type 2 diabetes mellitus is given in the following. Priority is given to the role of lipid metabolism, which is the main field of the reported spectroscopic studies. Furthermore, the technique of euglycemic hyperinsulinemic glucose clamp is described allowing determination of the individual insulin sensitivity of musculature. The role of IMCL in insulin resistance of the skeletal muscle is discussed. 

Evidence of a role of lipid peroxidation in the cellular toxicity of ozone has been obtained in in vitro studies in which human red cells were exposed to this oxidant gas. The possibility that lipid peroxidation is responsible for altered permeability of bacterial cell walls after ozone exposure was proposed by Scott and Lesher and has since been con-... 

Further indirect evidence of a role of lipid peroxidation in ozone toxicity has been obtained in studies in which animals deficient in vitamin E were found to be more susceptible to lethal concentrations of ozone and sublethal concentrations led to a more rapid utilization of this antioxidant vitamin. Although vitamin E deficiency potentiates the effects of ozone, it is not completely clear whether supranormal concentrations of vitamin E protect against ozone toxicity. Mice given tocopherol supplements were not protected against lethal concentrations of ozone, and the specific activity of lung hydrolases was found to be unrelated to dietary vitamin E concentration. However, other investigators have reported that additional supplementation with vitamin E above usual dietary concentrations lessens the extent of toxicity in animals that inhale ozone. ... 

Phleger, C. F. (1998). Buoyancy in marine fishes Direct and indirect role of lipids. Am. 

Biasi F, Albano E, Chiarpotto E, et al. 1991. In vivo and in vitro evidence concerning the role of lipid peroxidation in the mechanism of hepatocyte death due to carbon tetrachloride. Cell Biochem Func 9 111-118. 

Glende EA Jr., Hruszkewycz AM, Recknagel RO. 1976. Critical role of lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose 6-phosphatase. Biochem Pharmacol 25 21663-2170. 

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