Gut barrier function

Saadia, R., Schein, M., MacFarlane, C., Boffard, K. Gut barrier function and the surgeon. Br J Surg... 

The gastrointestinal (Gl) tract defends the host from toxins and antigens by both immunologic and nonimmunologic mechanisms, collectively referred to as the gut barrier function. Whenever possible, enteral nutrition (EN) is preferred over parenteral nutrition (PN) because it is as effective, may reduce metabolic and infectious complications, and is less expensive. 

Akp3 NM 007432 dlAP Duodenal-specific intestinal alkaline phosphatase (dIALP) Gut Fat absorption, gut barrier function, detoxyfication... 

Role of Intestinal Alkaline Phosphatase in Gut Barrier Function... 

LAP also appears to play several critical functions. LAP plays an important role in fatty acid absorption. LAP is able to dephosphor-ylate the phosphorylated fatty acid translocase FAT/CD36, which is thought to play a role in facilitating the transport of long-chain fatty acids into cells. In addition, Uke TNAP, LAP is able to dephos-phorylate LPS. The locahzation of the active site of LAP into the gut lumen allows LAP to protect gut barrier function and determine the composition of the gut microbiota. These functions of LAP, Uke those of TNAP, may have very important therapeutic appUcations. 

Jones C, Badger SA, Regan M, et al. Modulation of gut barrier function in patients with obstructive jaundice using probiotic LP299v. 

Lipidomics was also used to determine the effects of probiotic intervention on global lipidomic profiles in humans [145], Decreased mass levels of lysoPC, SM, and several PC species were detected after exposure of probiotic Lactobacillus rhamnosus GG bacteria for 3 weeks. These changes may be due to the metabolic events behind the beneficial effects ofL. rhamnosus GG on gut barrier function [146]. 

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