Non-human primate

Parkinson s disease (PD) 1. In a non-human primate model of PD endocannabinoid levels are elevated in the basal ganglia and may contribute to the generation of parkinsonian symptoms and/or to expression of levodopa-induced dyskinesia. The cerebrospinal fluid of untreated PD patients contains elevated levels of AEA 1. CB-) antagonists or biosynthesis inhibitors... 

Fuxe K, Andersson K, Nilsen OG, et al Toluene and telencephalic dopamine selective reduction of amine mrnover in discrete DA nerve terminal systems of the anterior caudate nucleus by low concentrations of toluene. Toxicol Lett 12 115—123,1982 Cause EM, Mendez V, Geller I Exploratory smdies of a rodent model for inhalant abuse. Neurobehav Toxicol Teratol 7 143—148, 1985 Gentry JR, Hill C, Malcolm R New anticonvulsants a review of applications for the management of substance abuse disorders. Ann Clin Psychiatry 14 233—245, 2002 Gerasimov MR, Ferrieri RA, Schiffer WK, et al Smdy of brain uptake and biodistribution of [llCjtoluene in non-human primates and mice. Life Sci 70 2811 — 2828, 2002... 

I noted above that two of the problems with the lesion technique in patients and non-human primates were that the process could not be reversed and information about time was lost. With magnetic stimulation. 

SAUNDERS P T, SHARPE R M, WILLIAMS K, MACPHERSON S, URQUART H, IRVINE D S, MILLAR M R (2001) Differential expression of oestrogen receptor alpha and beta proteins in the testes and male reproductive system of human and non-human primates. Mol Hum Reprod. 7 227-36. 

Ricaurte, G.A. Fomo, L.S. Wilson, M.A. DeLanny, L.E. Irwin, I. Molliver, M. and Langston, J.W. ( )3,4-Methylenedioxymethamphet-amine selectively damages central serotonergic neurons in non-human primates. JAMA 260 51-55, 1988. 

Montagna W. (1972). Skin glands of non-human primates. Am Zool 12, 109-124. 

Intravenous drug users using unsterilized needles Workers involved with non-human primates Food service handlers Patients with clotting factor disorders Individuals residing in health care institutions Hepatitis B and Hepatitis D Men having sex with other men Individuals with multiple heterosexual partners Intravenous drug users using unsterilized needles Recipients of blood products... 

Studies in rodents, dogs, and non-human primates have demonstrated all of the major types of health effects of lead that have been observed in humans, including cardiovascular, hematological, neurodevelopmental, and renal effects (EPA 1986a). These studies also provide support for the concept of blood lead concentration as a metric of internal dose for use in dose-response assessments in humans. 

Figure 7.2 Diurnal variation of extracellular dopamine in the non-human primate putamen. Dopamine concentrations (dm) as determined by high-pressure liquid chromatography of microdialysates obtained from the putamen of two rhesus monkeys across their 12 12 h lights-on (waking 7 00 am 7 00 pm) and lights off (sleep 7 00 pm-7 00 am) periods. Ten minute samples (2 pl/min sampling rate) were derived from nine individual 8 h sessions in each animal in which the sleep-wake state was monitored simultaneously by standard electrophysiological parameters.

In rats, lesions targeting presumptively wake-active dopaminergic neurons that extend dorsally from the VTA into the ventral periaqueductal gray have recently been shown to result in c. 20% reductions in wakefulness (Lu et al. 2006). Daytime sleepiness and SOREMs were reported in a non-human primate following systemic delivery of the dopamine neurotoxin MPTP (Daley et al. 1999), and this was subsequently confirmed in two additional animals (Daley... 

Freeman A., Morales J., Beck J. et al. (2006). In vivo diurnal rhythm of dopamine measured in the putamen of non-human primates. Sleep 29(Abstr. Suppl.), A69. 

Khroyan T.V., Platt D.M., Rowlett J.K., Spealman R.D. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology (Berlin). 168 124, 2003. 

Heidel JD, Yu Z, Liu JY, Rele SM, Liang Y, Zeidan RK, Kombrust DJ, Davis ME (2007) Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA. Proc Natl Acad Sci USA 104 5715-5721... 

Animal models of fear and anxiety have primarily used the rat, the mouse and, to a lesser extent, non-human primates 899... 

Barros, M. and Tomaz, C. Non-human primate models for investigating fear and anxiety. Neurosci. Biohehav. Rev. 26 187-201,2002. 

Neubert, R., G. Golor, R. Stahlmann, H. Helge, and D. Neubert. 1992. Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 4. Effects of multiple-dose treatment with 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus). Arch. Toxicol. 66 250-259. 

Schlemmer, R. F., and Davis, J. M. (1983) A comparison of three psychotomimetic-induced models of psychoses in non-human primate social colonies. In Ethopharmacology Primate Models of Neuropsychiatry, edited by K. A. Miczek, pp. 37-83. Alan R. Liss, New York. 

Dean, J.H., Comacoff, J.B., Labrie, T. and Barbolt, T.A. (1990). Assessment of immune responses in rodents and non-human primates—Implications in preclinical evaluation of proteins. In Preclinical Evaluation of Peptides and Recombinant Proteins, (Sundwall, A. et al., Eds.) Malmo. Skogs Grafiska AB, Stockholm, Sweden, pp. 23-34. 

Roselli CE, Resko JA. 2001. Cytochrome P450 aromatase CYP19) in the non-human primate brain distribution, regulation, and functional significance. J Steroid Biochem Mol Biol 79 247-253. 

Kolachana BS, Saunders RC, Weinberger DR. 1994. An improved methodology for routine in vivo microdialysis in non-human primates. J Neurosci Methods 55(1) 1-6. 

Le Poll B, Wertheim C, Goldberg SR (2007) High reinforcing efficacy of nicotine in non-human primates. PLoS One e230 l-8... 

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