Anti-retrovirals

HAART Highly active anti-retroviral therapy... 

Wallace VC, Blackbeard J et al (2007a) Pharmacological, behavioural and mechanistic analysis of HIV-1 gpl20 induced painful neuropathy. Pain 133(l-3) 47-63 Wallace VC, Blackbeard J et al (2007b) Characterization of rodent models of HIV-gpl20 and anti-retroviral-associated neuropathic pain. Brain 130(Pt 10) 2688-2702 Wechsler AF, Ho DD (1989) Bilateral Bell s palsy at the time of HIV seroconversion. Neurology 39(5) 747-748... 

Valentin G, Haas P, Gilmour D (2007) The chemokine SDFla coordinates tissue migration through the spatially restricted activation of Cxcr7 and Cxcr4b. Curr Biol 17 1026-1031 Wallace VC, Blackboard J, Segerdahl AR, Hasnie F, Pheby T, McMahon SB, Rice AS (2007) Characterization of rodent models of HlV-gpl20 and anti-retroviral-associated neuropathic pain. Brain 130(Pt 10) 2688-2702... 

Pope, M. T. Muller, A. (eds). Polyoxometalates From Platonic Solids to Anti-Retroviral Activity . Kluwer, Dordrecht, 1994. 

It is non-nucleotide reverse transcriptase inhibitor extensively metabolized by the CYP3A P450 isoform to hydroxylated metabolites and excreted in urine. It is indicated in combination with other anti-retroviral agents in a dose of 200 mg OD-BD for first 14 days. It is also been shown to be effective in the prevention of transmission of HIV from mother to new bom. 

It is indicated in treatment of HIV infection and is used in combination with other anti-retroviral agents in a dose 800 mg every eight hourly. 

A major impact in the treatment of HIV involves anti-retroviral therapy with APIs that belong to a class known as the avir family of highly active pharmaceuticals. A number of these avirs contain the l-phenyl-2,4-diamino-butan-3-ol fragment (Q). 

Instead, less traditional measures called surrogate endpoints are used to evaluate effectiveness. These are laboratory findings or signs that may not be a direct measurement of how a patient feels, functions, or survives, but are considered likely to predict benefit. For example, a surrogate endpoint could be the lowering of HIV blood levels for short periods of time with anti-retroviral drugs. 

World Health Organization (WHO). 2005a. Anti-retroviral Therapy. Available at http //www. who.int/hiv/topics/arv/en/ cost [Accessed April 5, 2005]. 

Piracy is a crime against humanity. Pirates steal and destroy wantonly. They rape and kill with abandon. Piracy is an inappropriate term for providing essential medicines to the world s poorest people. Medecins Sans Frontieres (MSF) broke the law when it began offering anti-retroviral therapy (ART) in Khayelitsha Township in South Africa in 2001. The crime against humanity would have been a studied failure to act in the face of the AIDS crisis. 

---