Gene dosage

To study the effect of an increased gene dosage of GR, Reichardt et al. (2000) and van den Brandt et al. (2007) generated rodent models of GR overexpression. These approaches confirmed that GR controls neuronal and immune functions in a dosage-dependent manner. These results highlight the importance of tight control of GR expression in target tissues and may explain... 

Ceballos-Picot, I., Nicole, A., Briand, P., Grimber, G., Delacourte, A., Defossez, A., Javoy-Agid, F., Lafon, M., Blouin, J.L. and Sinet, P.M. (1991). Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice animal model of gene dosage effects in Down s syndrome. Brain Res, 552, 198-214. 

Corder, E.H., Saunders, A.M., Strittmatter, W.J., et al. (1993) Gene dosage of apolipoprotein E type 4 allele and risk of Alzheimer s disease in late onset families. Science, 261, 921-923. 

Mann, D.M., Iwatsubo, T., Pickering-Brown, S.M., Owen, F., Saido, T.C., Perry, R.H. (1997) Preferential deposition of amyloid beta protein (Abeta) in the form of Abeta40 in Alzheimer s disease associated with a gene dosage effect of the apolipoprotein E E4 aUele. Neurosci. Lett., 221, 81-84. 

Lawrence, R.J., Earley, K., Pontes, O., Sdva, M., Chen, Z.J., Neves, N., Viegas, W. and Pikaard, C.S. (2004) A concerted DNA methylation/histone methylation switch regulates rRNA gene dosage control and nucleolar dominance. Molecular Cell, 13, 599-609. 

Saxton, T. M., Cheng, A. M., Ong, S. H., Lu, Y., Sakai, R., Cross, J. C., and Pawson, T. (2001). Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis, Curr Biol 11,662-70. 

Acampora, D., Avantaggiato, V., Tuorto, E, and Simeone, A. (1997) Genetic control of brain morphogenesis through Otx gene dosage requirement. Development 124 3639-3650. 

Black RS Jr, Guo Y, GeZ-D, Murphree S, Prabhu SD, Jones WK, Bolli R, Auchampach JA (2002) Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptor. Circ Res 91(2) 165—172... 

Poliak, MR, Chou, YH, Marx, SJ, Steinmann, B, Cole, DE, Brandi, ML, Papapoulos, SE, Menko, FH, Hendy, GN, Brown, EM and et al., 1994b, Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype, J Clin Invest 93 1108-1112 Posillico, JT, Wortsman, J, Srikanta, S, Eisenbarth, GS, Mallette, LE and Brown, EM, 1986, Parathyroid cell surface autoantibodies that inhibit parathyroid hormone secretion from dispersed human parathyroid cells, J Bone Miner Res 1 475-483... 

Luo, W., Wolska, B.M., Grupp, I.L., etal., 1996, Phospholamban gene dosage effects in the mammalian heart. Circ Res, 78(5), pp839 17. 

Gass, P., Wolfer, D. P., Balschun, D., Rudolph, D., Frey, U., et al. (1998) Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn Mem 5, 274-288. 

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