Cancer process

The most convincing data have been obtained from rodent models of cancers that revealed protective effects of curcumin against cancers of aU sites. Curcumin is able to inhibit all steps of cancer processes, initiation, progression, and promotion. These observations, combined with the apparent lack of toxicity of curcumin for doses up to 8 g/day for 3 mo suggest potential uses of curcumin as an anti-carcinogenic chemoprotective agent. ... 

We recently conducted experiments to extract mRNA from a cell model (MBA-MB-486 cell line of human breast cancer) processed in both frozen and FFPE blocks in a comparable fashion (unpublished data). The cell model system was prepared in three ways for comparison (1) Positive Control Fresh Cell Pellet Two flasks of cells were collected in a pellet, and stored at -70°C until use (2) Frozen Cell Block Two flasks of cells was embedded in OCT... 

Syngletary KW, Jackson SJ, Milner JA. 2005. Non-nutritive components in foods as modifiers of the cancer process. In Bendich A and Deckelbaum RJ, editors. Preventive Nutrition the Comprehensive Guide for Health Professionals, 3rd ed. Totowa, NJ Humana Press. 

To account for uncertainty regarding the variability in the stage of the cancer process at which monomethylhydrazine or its metabolites may act, a multistage factor of 6 is applied (Crump and Howe 1984) ... 

It is well established that diet can play a part in the cancer process (1,2,3). Food-borne chemicals, either additives or... 

The role of depurinating adducts and apurinic sites in the PAH-induced cancer process is controversial and has yet to be fully elucidated. There are lines of evidence that both support and refute this theory. In support of this theory, the levels of depurinating adducts of B[a]P correlated with mutations in the H-ras oncogene in DNA isolated from mouse skin papillomas initiated by this compound (Chakravarti et al. 1995). It is well known that the initiation of skin tumors in mice is associated with the formation of mutations in the H-ras gene [reviewed by Ross and Nesnow (1999)]. DB[a,/]P treatment of mouse skin forms papillomas which contain the H-ras codon 61 (CAA to CTA) mutation. These same mutations were induced in early preneoplastic skin within one day after DB[a,/]P treatment and appear to be related to DB[a,/]P-Ade-depurinating adducts. Studies have shown that apurinic... 

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