Riboflavine tablets

Supplement vitamin B2 deficiency states, impaired absorption, increased requirements Riboflavin 5-phosphate sodium, riboflavin Tablets, ampules 10-30 mg 0.4-1.4 mg 1.2-1.6 mg... 

Criterion Dmg release from six riboflavine tablete <0.2 mg/800ml... 

Samples of urine are analyzed for riboflavin before and after taking a vitamin tablet containing riboflavin. Concentrations are determined using external standards or by the method of standard additions, fluorescence is monitored at 525 nm using an excitation wavelength of 280 nm. 

Riboflavin is widely used in the pharmaceutical, food-enrichment, and feed-supplement industries. Riboflavin USP is adininistered orally in tablets or by injection as an aqueous solution, which may contain nicotinamide or other solubilizers. As a supplement to animal feeds, riboflavin is usually added at concentrations of 2—8 mg/kg, depending on the species and age of the animal (see Feeds AND FEED ADDITIVES). 

The SP procedure of water-soluble vitamins from multivitamin tablets is particularly challenging due to the diverse analytes of varied hydrophobicities and pfC. Water-soluble vitamins (WSVs) include ascorbic acid (vitamin C), niacin, niacinamide, pyridoxine (vitamin B ), thiamine (vitamin Bj), folic acid, riboflavin (vitamin B2) and others. While most WSVs are highly water soluble, riboflavin is quite hydrophobic and insoluble in water. Folic acid is acidic while pyridoxine and thiamine are basic. In addition, ascorbic acid is light sensitive and easily oxidized. The extraction strategy employed was a two-step approach using mixed solvents of different polarity and acidity as follows ... 

Spectrofluorimetry differs from absorption spectrophotometry in not yielding an absolute scale of values. For this reason it is essential to employ a reference standard for quantitative measurements. For example, some pharmacopoeial tests, such as the test for uniformity of content for digitoxin tablets, employ a spectrofluorimefric assay and comparison wi an ofticial reference standard. Quantitative Spectrofluorimetry has been proposed for a munber of naturally fluorescent compoimds, including ergometrine, riboflavine, tiie catechol-amines, phenothiazines, the barbiturates (at pH 13), and certain antibiotics such as chlortetracycline and oxytetracycline. 

A 30-year-old woman, a heterozygote for hypophosphatasia, who had been taking two tablets of a multivitamin formulation (pyridoxine hydrochloride 100 mg, riboflavin butyrate 30 mg, nicotinamide 40 mg, biotin 0.05 mg, ascorbic acid 100 mg) once daily for 6 years, had severe skin eruptions and pruritus on exposure to the sun. The minimum erythema doses for UVB (20 mJ/ cm ) and UVA (4 J/cm ) were lower than normal only for UVB (reference ranges 60-100 mJ/cm for UVB and below 10 J/cm for UVA). Patch and photopatch tests with the constituents of the tablets produced reactions to pjTidoxine and pjridoxal phosphate only. 

Anaphylaxis has been reported in a boy who took a multivitamin tablet containing riboflavin (3). 

Morrison A, Chapman D, Campbell J. Further studies on the relation between in vitro disintegration time of tablets and the urinary excretion rates of riboflavin. J Am Pharm Assoc 1959 48 634-637. 

Morrison A, Campbell J. The relationship between physiological availability of salicylates and riboflavin and in vitro disintegration time of enteric coated tablets. J Am Pharm Assoc 1960 49 473 78. 

Middleton E, Davies J, Morrison A. Relationship between rate of dissolution, disintegration time, and physiological availability of riboflavin in sugar-coated tablets. J Pharm Sci 1964 53 1378-1380. 

Ranitidine Tablet Cores (150 mg) Ranitidine Tablet Cores (300 mg) Riboflavin see Vitamin B2 Rifampicin Tablets (450 mg)... 

H. Wei and Y. Cheng, Separation and Detection of Vitamins B1 (Thiamine), B2 (Riboflavine), B6 (Pyridoxine) and Nicotinamide in Compound Vitamin B Tablets with Use of Micellar TLC, Yaowu-Fenxi-Zazhi, 10 371 (1990). 

Li, K., 2002. Simultaneous determination of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets by reversed-phase ion-pair high performance liquid chromatography. Biomedical Chromatography. 16 504-507. 

G. Buchholcz, A. Kelemen, T. Sovany, and K. Pintye-Hodi, Matrix tablets based on a carrageenan with the modified-release of sodium riboflavin 5 -phosphate, Pharmaceut. Develop. Tech., 1-8, 2014. 

Bodson, C., et al., Comparison of FT-NIR transmission and UV-vis spectrophotometry to follow the mixing kinetics and to assay low-dose tablets containing riboflavin. J. Pharm. Biomed Anal., 41 783-790 (2006). 

The simultaneous determination of the B vitamins, thiamine, riboflavin, pyridoxal, pyridoxine, and pyridoxamine in a pharmaceutical product using CZE was described by Huopalahti and Sunell (90). Hydrochlorid acid was used for the extraction of the vitamins from the multivitamin-multimineral tablet. The applied potential was 6.0 kV, and a 75-p.m fused-silica capillary tubing was used. The electrolyte used was a 20-mM sodium phosphate buffer pH 9.0. A clear separation of standards as well as of the pharmaceutical sample is shown in Figure 14. This method appears to be a fast and simple technique for the simultaneous determination of water-soluble vitamins in pharmaceutical products, where the... 

The first successful separation of calcium pantothenate in multivitamin preparations that allowed the quantitative determination in <5 min was reported by Jonvel et al. (65). They used a 20-cm Nucleosil 7 Cig reversed-phase column, an acetic acid-water (5 95, v/v) mobile phase at a flow rate of 2 mL/min, and a refractometer as a detector. Samples were simply dissolved in the mobile phase and analyzed without any internal standard. Mean recoveries of the assays of commercially available calcium pantothenate tablets containing also thiamine, riboflavin, niacinamide, and pyridoxine ranged Ifom 96.8% to 104.4%. The detection limit was 50 ng injected. 

Compound Tablets of Aneurine, B.P.C. Contain 1 mg each of aneurine hydrochloride and riboflavine and 15 mg of nicotinamide. 

---