Aneurine Hydrochloride

Aneurine Hydrochloride Thiamine Chloride Vitamin Vitamin Bi Hydrochloride... 

Synonyms Vitamin Bj Aneurine hydrochloride Thiamine hydrochloride Thiadoxine Thiamin Vitamin Bj hydrochloride... 

Acharya V, Store SD, Golwalla AF (1969) Anaphylaxis following ingestion of aneurine hydrochloride. J Indian Med Assoc 52 84-85... 

Anetol. See Anethole Aneurine. See Thiamine Aneurine hydrochloride. See Thiamine HCI Aneurine mononitrate. See Thiamine nitrate Anfomui 01T. See 2-Heptadecenyl-4,4-bishydroxymethyl oxazoline Anfomui S4. See Sorbitan oleate Anfomui S6. See Sorbitan isostearate Anfomui S43. See Sorbitan sesquioleate Anfomui S50. See Sorbitan oleate Angelica (Angelica archangelica)... 

Synonyms Aneurine hydrochloride Thiamin chloride Thiamine chloride hydrochloride Thiamine dichloride Thiamine hydrochloride Thiamin hydrochloride Thiaminium chloride hydrochloride Vitamin Bi hydrochloride Definition Chloride-hydrochloride salt of thiamine Empiricai C12H18CI2N4OS Formuia C12H17CIN4OS HCI Properties Small wh. cryst. orcryst. powd., nut-like odor sol. in water, glycerol si. sol. in alcohol insol. in ether, benzene m.w. 337.30 m.p. 248 C (dec.)... 

For solutions Prepare a dilution of the sample to contain about 0 1 mg of aneurine hydrochloride per ml and having an acid concentration equivalent to O OIN. Transfer 5 ml to a 50-ml graduated flask, add 10 ml of 50 per cent ethanol, mix, add 5 ml of diazotate reagent and again mix. Place in a water-bath at 20° for twelve minutes and then dilute to 50 ml with wopropyl alcohol. Determine the extinction at 520 m u in a 1-cm cell, subtract the value of a reagent blank and read off the amount of aneurine from a calibration curve. 

Stock Aneurine Solution 100 jtig per ml. Prepare this from the British Standard preparation, or a sub-standard of equal purity. Dissolve a weighed amount of aneurine hydrochloride equivalent to 50 mg of the International Standard in sufficient 0 2N hydrochloric acid to make 500 ml. This solution is stable for several months if stored in a refrigerator i.e. below 5 ). 

Injection of Aneurine Hydrochloride, B.P. A sterile solution containing 25 mg of aneurine hydrochloride in 1 ml of water for injection. For assay either the fluorimetric technique on a suitable dilution or the silicotungstic acid precipitation method given above can be used. For the latter, 1 ml of injection is diluted to 50 ml for assay. 

Tablets of Aneurine Hydrochloride, B.P. The usual strength of this tablet is 3 mg and no difficulty is experienced in following either the fluorimetric or silicotungstic acid methods given above. It must be realised that the results of assay by the latter method may give rather different figures from the fluorimetric method.

Compound Tablets of Aneurine, B.P.C. Contain 1 mg each of aneurine hydrochloride and riboflavine and 15 mg of nicotinamide. 

Elute the aneurine hydrochloride with 150 ml of 2N hydrochloric acid and measure the extinction of a 1-cm layer at about 246 m//. Calculate the weight of aneurine hydrochloride in a tablet of average weight using an E(1 per cent, 1 cm) of 41b at 246 m//. 

Thiamine mononitrate, Ci2Hi7N504S, Mol. Wt. 327-4, is assayed in the U.S.P, by a method similar to the fluorimetric method given above using aneurine hydrochloride as a standard it is necessary to multiply by 0-9706 to convert to mononitrate. 

Strong Compound Tablets of Aneurine, B.P.C. These tablets contain 2 mg of pyridoxine hydrochloride together with nicotinamide (20 mg), aneurine hydrochloride (5 mg) and riboflavine (2 mg). The J8.P.C. prescribes a microbiological test for determination of the aneurine and pyridoxine, but the alginic acid separation method of Foster and Murfin is also applicable (see p. 461). 

Aneurine hydrochloride solution. A solution in water containing 1,000 fig aneurine hydrochloride per ml. 

Vitamins solution. Inositol 0 5 per cent, choline chloride 0 1 per cent, /)-aminobenzoic acid 0 05 per cent, aneurine hydrochloride 0 1 per cent and biotin 0 0005 per cent in 20 per cent ethanol. 

---