Sugar coated tablets

Titanium dioxide is used extensively to impart a white color to film-coated tablets, sugar-coated tablets, and gelatin capsules. It is also used in lakes as an opacifier, to extend the color. See Titanium dioxide for further information. 

Supplement vitamin Bi deficiency states, impaired absorption or increased requirements (pregnancy, lactation, alcoholism) Therapy beriberi, Wernicke s encephalopathy, neuritis, polyneuritis (alcoholic and toxic), neuralgia, myalgia, myocardia, disorders of the intermediate metabolism Thiamine chloride and hydrochloride, thiamine mononitrate, cocarboxylase, thiamine pyrophosphate Tablets, sugar-coated pills, dragees, ampules 50-300 mg 0.3-1.2 mg 1.0-1.4 mg... 

Sugar coating is time-consuming, requires skilled operators, and increases the tablet weight, sometimes to twice that of the uncoated core. 

Erodings of Slow-Releasing Core Tablets. The sustained-dose portion of a dmg is granulated with hydrophobic materials such as waxes, fatty acids, or fatty alcohols and compressed into a core. The initial dose is added to the core by a modified sugar coating process or by compression coating. Thus, a tablet within a tablet is created. The core erodes slowly to release the active ingredient. 

Baugh and co-workers exposed solutions of phenylbutazone to the light of a projector lamp in the presence of typical dyes used to colour sugar-coated tablets. Erythrosine sodium photosensitized decomposition of the drug via, it was suggested, singlet oxygen [134]. 

The flow-through cell is applicable not only for the determination of the dissolution rate of tablets and sugar-coated tablets, but has also been applied to suppositories, soft-gelatin capsules, semisolids, powders, granules, and implants. A small volume cell containing the sample solution is subjected to a continuous stream of dissolution media. The dissolution... 

Coat Physical protection of tablet Sugar, methylceUulose, cellulose acetate... 

The traditional tablet coating is a sugar coat applied in stages. First the tablet surface is sealed... 

Sugar-coated products have been marketed that contain KCl in a wax matrix (Slow-K and Kaon-Ct) and are purportedly slow- and controlled-release preparations. Available evidence indicates that these slow-release forms of KCl are occasionally capable of causing local tissue damage and therefore prol5ably should be used with caution for K+ supplementation. Solutions of potassium gluconate, like the tablets, also have been associated with intestinal ulceration. Microencapsulated KCl preparations Micro-K, K-Dur) that are neither enteric coated nor contained within a wax matrix appear to be superior to the wax matrix formulation. 

In contrast, oral administration of a willow bark extract showed a low bioavailability of salicin (98). After ingestion of commercial sugar-coated tablets containing willow bark extract corresponding to a total amount of 54.9mg (0.192mmol) salicin, the serum of 12 volunteers showed a peak concentration of only 0.13 pg/mL salicylic acid this is only 5% of the serum... 

Nakabayashi, K.,Shimamoto,T., and Mima,H. (1980), Stability of packaged solid dosage forms. II. Shelf-life prediction for packaged sugar-coated tablets liable to moisture and heat damage, Pharm. Chem. Bull., 28,1099-1106. 

Start with formulation No. 1 by means of the manual sugar coating procedure during some hours. After changing to formulation No. 2 continue with the same procedure until homogeneous coloured sugar coated tablets are obtained. 

Tablet sugar Used to coat a formed tablet for Sugar liquid glucose,...

Shellac Above pH 7 Original enteric coating material, originally used in sugar-coated tablets high pH required for dissolution may delay drug release natural product which exhibits batch-to-batch variability... 

Several authors have made proposals for the most convenient size of tablet for sugar coating. A further rule has been established according to which the convex radius should be between 0.7 and 0.75 times the tablet diameter and the band height between 0.07 and 0.12 times that diameter. However, for calculation of the band height only a factor of 0.12 is advisable, since, otherwise, the minimum value of lmm will be fallen short of by far [53,57-60]. For film coating the recommended convex radius is 1.5 times the tablet diameter (less curved tablets are preferred). 

Figure 26 shows a comparative study of uncoated tablet and sugar-coated tablet after a barrier to water with copovidone 0.5 mg/cm2 of the warm tablet cores using a 10% solution in ethanol. During two years the coating tablets (with initial humidity 2.5%) remained stable and dissolution profiles were similar to the initial time with similarity f2 = 82 observed and friability decreased from 0.25% (uncoated cores) to 0.02% (coated tablets). 

Contents. Note the total number of tablets or other preparation in the container, together with an estimate of the total number which the container could hold if filled. Note the shape (flat, bevelled, biconvex, etc.), whether compression-coated, film-coated, enteric-coated, or sugar-coated, markings (numbers, letters, symbols, or score marks), exterior and interior colour, layered and core tablets, and mean weight, diameter, and thickness. 

---