Pyridoxine.hydrochloride

Description of Method. The water-soluble vitamins Bi (thiamine hydrochloride), B2 (riboflavin), B3 (niacinamide), and Be (pyridoxine hydrochloride) may be determined by CZE using a pH 9 sodium tetraborate/sodlum dIhydrogen phosphate buffer or by MEKC using the same buffer with the addition of sodium dodecyl-sulfate. Detection Is by UV absorption at 200 nm. An Internal standard of o-ethoxybenzamide Is used to standardize the method. 

Nutrients and diet supplements without claims of therapeutic effects are considered foods, and are thus regulated by the U.S. Food and Dmg Administration. These are further subject to specific food regulations. Specifications for pyridoxine hydrochloride (7) for foods are given in the Food Chemicals Codex (80) and for pharmaceuticals in the US. Pharmacopeia (81). General test methods have been summarized (82). 

The primary uses of pyridoxine hydrochloride are in multivitamin supplement tablets and for fortification of human food and animal feed, especially for poultry and pigs. Most breakfast cereals and infant formulas in the United States are supplemented. Lesser amounts are used therapeutically to correct deficiencies or to treat specific disorders. Pyridoxine hydrochloride has been used experimentally to treat a variety of conditions with varying degrees of effectiveness (4,23). Pyridoxine hydrochloride is readily incorporated into premixes and foods. 

Pyridoxine Hydrochloride, MSDS 11076, Hoffmann-1,aRoche Inc., Nudey, N.J., 1997. 

Pyridoxal hydrochloride, pyridoxamine hydrochloride and pyridoxine hydrochloride (vitamin Bg) see entries in Chapter 6. 

Pyridoxin-Hydrochlorid kann in In Salzsaurc selektiv an der 4-Hydroxymethyl -Gruppe zum 3-Hydroxy-2,4-dimethyl-5-hydroxymethyl-pyridin (—99% d.Th.) reduziert werden (vgl. a. S.604)4 ... 

CjHiiNO 65-23-6) see Cicletanine Pyiidofylline pyridoxine hydrochloride (C H 2C1NOj 58-56-0) see Pirisuduiiol... 

Supplemental doses of pyridoxine hydrochloride (vitamin B6), 50 mg/ day, are recommended to prevent the peripheral neuropathy associated with isoniazid administration. 

Vitamin formulations that may be added to foods are pyridoxine hydrochloride, pyridoxine 5-phosphate, and pyridoxine dipatmitate [403]. 

Fixed dose combinations of vitamins with anti TB drugs except combination of isoniazid with pyridoxine hydrochloride (vitamin Bg). 

Pyridoxine hydrochloride (vitamin Bg) [58-56-0] M 205.7, m 209-210 (dec). Crystd from EtOH/acetone. 

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