Amine catechol

Weak bases (pK, < 8) Catechol- amines 6 - 7.4 Ionization is suppressed retention dependent upon the nature of the solute. 

Ary, T.E., and Kominskey, H.L. Basis of phencyclidine s ability to decrease the synaptosomal accumulation of [3H]-catechol-amines. J. Pharmacol 61 401-405, 1980. 

Brzezinski J. 1972. Effect of poisoning with phosphorus organic insecticides on the catechol amine levels in rat plasma, brain, and adrenals. Dissertationes Pharmaceuticae et Pharmacologicae 24 217- 220. 

Inhibition of the enzymes involved in dopamine degradation, catechol-amine-oxygen-methyl-transferase Lullmann, Color Atlas of Pharmacology 2000 Thieme All rights reserved. Usage subject to terms and conditions of license. 

The therapeutic efficacy in the treatment of tachyarrhythmias is based upon the reduction of the influence of endogenous catechol-amines on the sinus node and the AV node. 

M.A. Lipton u. S. Vdenfriend, U.S., Publish Health Serv. Publ. No. 1836, 7-12 (1957-1967) , .Catechol Amines, Synthesis and Synthesis Inhibitors". 

Artificial catechol-amine humic acid Spin content X 10 2.3 54 23... 

It may indeed be, as Bacq and Fisher (2) and Goldenberg and co-workers (6) suggest, that the synthesis of adrenaline is through the transmethylation of noradrenaline as a final step and that the deactivation of noradrenaline is through the transmethylation of noradrenaline as an initial step. In this connection it is of interest that Shaw (13) found in his studies on the oxidation of adrenaline and noradrenaline by an arsenomolybic reagent that the former catechol amine was about twelve times more rapidly oxidized and that an increase of about five times was from some phenomenon associated with the addition of alkali. Just what the phenomena noted by Shaw are due to is not clear but they do demonstrate that an order of five to twelve times difference in oxidation rates between noradrenaline and adrenaline may be on some simple chemical reaction basis. 

To understand the role of an element in living systems we need to know not only the local accumulation and the entire amount of the element in the organism, but also the chemical forms in which it is present. Aluminum is an A-type metal or hard acid and therefore the most likely Al3+ binding sites are oxygen donors of various biomolecules, particularly if these donors are negatively charged [19, 20]. The most important aluminum binding sites are phosphate, carboxylate, catecholate, amines, thiolates, amino acids, nucleic... 

Creveling, C. R., and Daly,J. W., Assay of Enzymes of Catechol Amines. Supp. 153... 

Catechol Amine Biosynthesis and MetaboUsm, Assay of Enzymes of Catecholamines and Catecholamine Metabolites, Estimation of Total (Free + Conjugated), in... 

Catechol Amines, Determination of (Weil-Malherbe). Supp. 119... 

Enzymes, Assay of in Catechol Amine Biosynthesis ami Metabolism (Creveling... 

Spectrofluorimetry differs from absorption spectrophotometry in not yielding an absolute scale of values. For this reason it is essential to employ a reference standard for quantitative measurements. For example, some pharmacopoeial tests, such as the test for uniformity of content for digitoxin tablets, employ a spectrofluorimefric assay and comparison wi an ofticial reference standard. Quantitative Spectrofluorimetry has been proposed for a munber of naturally fluorescent compoimds, including ergometrine, riboflavine, tiie catechol-amines, phenothiazines, the barbiturates (at pH 13), and certain antibiotics such as chlortetracycline and oxytetracycline. 

Spin-casting techniques have also been used to prepare imprinted thin films. Makote and Collinson recently prepared metal oxide thin films imprinted with recognition sites for dopamine [18], The dopamine template was loaded at 4 mole % in a sol with a 10 1 ratio of tetramethoxysilane and phenyltrimethoxysilane. The prepared film had a thickness of ca. 450 nm. CV analysis found that 90% of the templates could be removed by washing the films with pH 7 phosphate buffer. The opened receptor sites offered selective binding for related molecules containing catechol amines, such as dopamine, epinephrine and norepinephrine, as determined by CV. The use of phenyltrimethoxysilane turns out to be an essential ingredient for the gel matrix and is believed to provide some complementary affinity for the catechol amines via hydrophobic and/or 7i-stacking interactions. 

The enhancement of ozone injury in animals by activity during exposure to ozone has been the most striking demonstration of all. The lethal outcome of otherwise noninjurious concentrations of ozone results undoubtedly from a multiplicity of factors in addition to that of the more obvious reactions associated with activity such as increased respiration and circulation rates. Hormonal releases, for example, in the form of catechol amines, epinephrine, and norepinephrine, as well as in certain adrenocorticosteroids (compounds B and F) have been reported in tumbled rats (9), a condition not completely unrelated to that in cage-activated rats, especially during the terminal phases on the exposure. How much of a role these hormones play in these experiments, however, still remains to be determined. 

New Mexico lignite humic acid Artificial catechol-amine 28.0 300... 

Certain physiologic and dietary materials affect the platelet reactions. Catechol amines enhance platelet aggregation and promote thrombus formation. Fatty acids appear to enhance platelet aggregation, with saturated fatty acids being more effective than unsaturated fatty acids. Thrombosis is produced in the dog by single rapid infusion of long-chain saturated fatty acids but chronic slow infusions are nonthrombogenlc. Apparently the dog has sufficient thrombolytic power to handle the latter situation. 

In addition to many early examples, biological response has been found to be quantitatively linearly dependent on log P or it in the inhibition of the Hill reaction >activity of penicillins, toxicity of benzoic acids to mosquito larvae , phenol coefficients , cholinesterase inhibitors , and catechol-amine activity . 

Monoamine oxidase Vertebrate tissues 255,000 0.07 4 -t- Oxidative deamination of catechol amines and others (Yl)... 

Carbon suboxide, 52 Carbonylation, 148, 149, 216 Carbonyl chlorofluoride, 48, 54 Carbonyl cyanide, 60-61 N,N -Carbonyldiimidazole, 61 1,1-Carbonyldi-l,2,4-triazole, 61 N-Carbonylsulfamic acid chloride (N-Carbonylsulfamyl chloride), 61 Carboxamides, 270 Carboxamine-N-sulfochlorides, 70 p-Carboxybenzenediazonium chloride, 62 p-Carboxybenzenesulfonazide, 62 Carboxylation, 15, 16 Carboxylic acid anhydrides, 133 Carboxylic acid N,N-dimethylamines, 153 Carboxylic anhydrides, 409-410 p-Carboxyphenylhydrazones, 62 Cardenolides, 130, 131 (S-Carotene, 19 /-Carvone, 451, 452 i//-Caryophyllene, 149, 150 Catechol, 65, 233 Catechol amines, 159 Catechyl phosphorus tribromide, 63 Catechyl phosphorus trichloride, 63 Cis-Cecropia juvenile hormone, 261 Cedrene, 234, 235 a-Cedrene, 349 /3-Cedrene, 349 Cendranoxide, 234, 235 Cephalosporin C, 48 Ceric ammonium nitrate, 63-65 Ceric sulfate. 65 Cesium fluoride, 346 trans-Chalcone oxide, 422 Chalcone phenylhydrazones, 257, 258 Chalcones, 406 Chloramine, 65-66, 69 Chloranil, 66-67, 113, 116, 401,454... 

DMSO is an excellent solvent-catalyst for the trimethylsilyation of catechol amines with hexamethyldisilazane.31h The reaction is usually complete in 5-10 min. at 80°. The primary amino groups are then converted by reaction with various aliphatic ketones into Schiff bases suitable for gas chromatography. 

Phosgene for 2-hydroxyamines related to catechol amines (Gyl-lenhaal and Vessman 1988) ... 

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