Relationship between physiological

Relationship between physiological action and chemical constitution in the fluoroacetate series 133... 

Relationship between Physiological Action and Chemical Constitution in the Fluoroacetate Series1... 

Shulman, G.E., Revina, N.I. and Safyanova, T.E. (1970). Relationship between physiological condition and oogenesis feature of pelagic fish (In Russian). Trudy VNIRO 59,96-108. 

Uhlinger, D.J., and White, D.C. (1983) Relationship between physiological status and formation of extracellular polysaccharideglycocalyx in Pseudomonas atlantica. Appl. Environ. Microbiol. 45, 64—70. 

There are many quantitative relationships between physiological action and logP or log P pp A few examples are given here. 

Morrison A, Campbell J. The relationship between physiological availability of salicylates and riboflavin and in vitro disintegration time of enteric coated tablets. J Am Pharm Assoc 1960 49 473 78. 

Some Applications of Gas-Liquid Chromatography in the Investigation of the Relationship Between Physiological Stress and Physical Activity Proc. Anal. Div. Chem. Soc. 14(9) 248-249 (1977) CA 88 33996z... 

Harris, G. P. (1971b). The ecology of corticolous lichens. II. The relationship between physiology and environment. J. Ecol. 59, 441-452. 

The history of quantitative structure-activity relationships dates back to the last century, when Crum-Brown and Fraser in 1865 postulated that there ought to be a relationship between physiological activities <1> and chemical structures C. Later, Richet correlated toxicities with aqueous solubility. Around 1900, Meyer and Overton found linear relationships between the narcotic potencies of organic compounds and their partitioning behavior. In the mid-1930s, Hammett defined a reaction constant p to describe the reactivity of aromatic systems R, expressed by rate constants k (or equilibrium constants K) and a parameter o to describe the electronic properties of aromatic substituents X (1 equation 1) (see Linear Free Energy Relationships (LFER)) ... 

In another attempt to relate degree of ionization with antibacterial activity, the effect of pH of the medium on the antibacterial activity was studied (27,28). Activity increased with increase in pH only up to the point at which the dmg was 50% ionized, and then decreased. The interpretation of this was that sulfonamides penetrate the bacterial cell in the unionized form, but once inside the cell, the equiUbrium between ionized and unionized forms is reestabhshed, and the activity is due to the ionized form. For optimum activity, a sulfonamide should have a p that provides half-dissociation at the physiologic pH in the area where it is absorbed. This observation also provided an explanation of the paraboHc relationship between piC and MIC (24). 

The physiological effect of a particular lens can be determined by measuring the increased thickness of the cornea after lens wear studies have shown the relationship between the DkjD of a lens and the subsequent swelling of the underlying cornea (20,21). 

A model can be defined as a set of relationships between the variables of interest in the system being investigated. A set of relationships may be in the form of equations the variables depend on the use to which the model is applied. Therefore, mathematical equations based on mass and energy balances, transport phenomena, essential metabolic pathway, and physiology of the culture are employed to describe the reaction processes taking place in a bioreactor. These equations form a model that enables reactor outputs to be related to geometrical aspects and operating conditions of the system. 

Romijn, J. A., Coyle, E. R, Sidossis, L. S., et al., 1996. Relationship between fatty acid delivery and fatty acid oxidation during strenuous exercise. Journal of Applied Physiology 79 1939—1945. 

It can be seen that if KA< v then negative and/or infinite values for response are allowed. No physiological counterpart to such behavior exists. This leaves a linear relationship between agonist concentration and response (where Ka = v) or a hyperbolic one (KA>v). There are few if any cases of truly linear relationships between agonist concentration and tissue response. Therefore, the default for the relationship is a hyperbolic one. 

Physiologically Based Pharmacodynamic (PBPD) Model—A type of physiologically-based dose-response model which quantitatively describes the relationship between target tissue dose and toxic end points. These models advance the importance of physiologically based models in that they clearly describe the biological effect (response) produced by the system following exposure to an exogenous substance. 

For future research in this field, in addition to physiological and biochemical approaches, genetic analysis will be essential in the establishment of causal relationships between the induction of a stress protein and the establishment of tolerance to the stress condition. In most cases it is not difficult to detect the induction of new proteins during stress. However, the induction of new proteins does not necessarily establish stress tolerance it may well be the consequence of damage caused by stress conditions. Thus, genetic mutants will be necessary to test the physiological role of a stress protein. 

Ben-Hayyim, G. (1987). Relationship between salt tolerance and resistance to polyethylene glycol-induced water stress in cultured citrus cells. Plant Physiology, 85, 430-4. 

Farquhar, G.D., O Leary, M.H. Berry, J. A. (1982). On the relationship between carbon isotope discrimination and the intercellular carbon dioxide concentration in leaves. Australian Journal of Plant Physiology, 9, 121-37. 

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