Response defined

Vendor s Responsibility - Defines the terms of contractual commitments on the part of the vendor. 

The standard requires that the supplier s management with executive responsibility define and document its policy for quality. 

In what document is the management representative s authority and responsibility defined ... 

Team responsibilities Define PSM criteria and goals for Company X evaluate current PSM status develop a plan to build on what s in place and address gaps develop specific PSM systems select a test site and install a pilot system measure and monitor its progress refine systems as needed. [Limits]... 

While the overall policy responsibility for health and safety rests with senior managers, all employees within the organization, irrespective of their duties, have some degree of responsibility for carrying out the policy. Where appropriate, nominated persons with specific responsibilities for health and safety should be named with a summary of their responsibilities defined. It follows that there should be a procedure established whereby deputies are available during the nominated person s absences. 

These responses are used for response in the concentration metameter for the fit for the second curve. For example, the response defined by real data for curve 1 at 3 nM is 0.06. The corresponding equiactive concentration from curve 2 is given by Equation 12.6, with Response = 0.06, basal = 0, and the values of n, E nax, and EC derived from the fit... 

FIGURE 4.5 Typical ISE response curves to monovalent cations (solid circles) with a response slope of 59.2mV decade-1 and to divalent cations (open circles) with a Nemstian slope of 29.6mV decade-1. Intercepts of the linear ranges of sensor responses define the lower and higher detection limits. 

Scope and define component responsibilities Define component and/ or system interface Specify desired component operations... 

There are no safety and efficacy data on treatment for longer than 48 weeks. Consider discontinuing therapy after 12 to 24 weeks of therapy if the patient has failed to demonstrate an early virologic response, defined as undetectable HCV RNA or at least a 2log- o reduction from baseline in HCV RNA titer by 12 weeks of... 

The ITAE is sensitive to initial and, to a certain extent, unavoidable deviations. Optimum control responses defined through ITAE consequently have short response times and larger overshoots than in the case of the other two aiteria. However, ITAE has proven to be very useful for evaluating the regulation of coating processes. 

In 2001, Weber et al. [82] showed in a study cohort of 40 patients with locally advanced adenocarcinoma of the esophagogastric junction that prediction of histopathologic response is possible by metabolic imaging with [ F]-FDG as early as 2 weeks after induction of chemotherapy. Application of the criterion metabolic response—defined as a reduction of baseline SUV of more than 35%—allowed prediction of clinical response with a sensitivity of 93% and specificity of 95%, respectively (Fig. 2). 

Wieder et al. [80] evaluated the time course of therapy-induced changes in tumor glucose metabolism during chemoradiotherapy of esophageal SCC in a cohort of 38 patients. Early metabolic response, defined as a reduction of baseline SUV of more than 30%, predicted histopathologic response 2 weeks after induction of chemotherapy with a sensitivity of 93% and a specificity of 88%, respectively. Changes in tumor metabolic activity early in the time course of preoperative chemoradiotherapy were also significantly correlated with patient survival (p < 0.011). 

HCV RNA (early virologic response defined as HCV RNA undetectable or >2 logjo lower than baseline at 12 weeks and 24 weeks) for patients who lack an early viral response at 12 weeks, chance of sustained viral response is 13% for patients who lack an early viral response at 24 weeks, chance of sustained viral response is near zero in consultation with experts, consider stoppi ng peginterferon therapy if vi ro-logic response absent at 12-24 weeks... 

E. Therapeutic response The safety and efficacy of a single intravenous dose of Remicade were assessed in a randomized, double-blind, placebo-controlled study of patients with moderate to severe active Crohn s disease who had failed standard therapy. The primary end point was the proportion of patients who experienced a clinical response, defined as a minimum decrease in the Crohn s Disease Activity Index from baseline at the 4-week evaluation and without an increase in Crohn s... 

Most efficacy trials with reboxetine have so far only been published in review articles ( 178). Most of these articles did not have peer review and do not contain the full details concerning methodology or results. This fact limits the ability to accurately determine its relative efficacy and tolerability. In short-term (4 to 8 weeks), placebo-controlled clinical trials, reboxetine produced a response (defined as at least a 50% reduction in severity scores) in 56% to 74% of patients. These results were statistically superior to placebo in most studies. Reboxetine was also found to be as effective as imipramine and desipramine in four double-blind, randomized, active-controlled (but not placebo-controlled) studies involving more than 800 outpatients or inpatients with major depression. Reboxetine produced equivalent antidepressant response rates compared with fluoxetine in two clinical trials, one of which was also placebo-controlled. However, reboxetine was reported to have improved social motivation and behavior more than fluoxetine as assessed by the newly developed Social Adaptation Self-Evaluation Scale. In all of the studies, reboxetine had a similar time (i.e., 2 to 3 weeks) to onset of the antidepressant efficacy as do other antidepressants. 

Are the management responsibilities defined in SOPs promptly detected ... 

Process owners require a defined set of responsibilities to maintain a vibrant and effective process that continues to support product quality deliverables. Having roles and responsibilities defined provides owners with the structure and parameters... 

A physical insight into eqs. (2)-(5) is gained by considering the equivalent circuit shown in Figure 4, which displays the same frequency response defined in eqs. (2)-(5). The membrane capacitance per unit area Cjj, appears in series with the access impedances p and Pa/2, while the term CTfl (1-1.5p) provides for the conductance of the shunting extracellular fluid. Hence the time constant T which determines the frequency where the impedances l/(jjCmR and (p + Pa/2) are equal is given by eq. (5). 

For an enthusiastic uniform support within the plant, each level in the organization management must visibly champion and continuously reinforce the policies which are designed and implemented to reduce spills, releases, fires and explosions. There must also be clear roles and responsibilities defined. Each type of change can be different, each review can be different, but Table 11—2 can assist in establishing a review procedure for a medium or large organization. 

Are IT Management roles and responsibilities defined (e.g., remit, job description) ... 

Impedance, on the other hand, includes the transient response of the system as well as the long-term, steady-state response defined by Ohm s law. The entire time course of impedance is usually captured by transforming the measurement to the frequency domain. This is an inverse transform in which transient responses occur at high frequencies and long-term, steady-state responses are approached at low frequencies. 

The study coordinator is generally considered the linchpin in the day-to-day activities of clinical research. Without this key individual, sites would be hard pressed to perform studies in a quality and timely fashion because the coordinator s responsibilities define clinical trial conduct. 

These responses are used for Response in the concentration metameter for the fit for the second curve. For example, the response defined by real... 

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