Metabolic imaging

Callender TJ, Morrow L, Subramanian K, et al. 1993. Three-dimensional brain metabolic imaging in patients with toxic encephalopathy. Environ Res 60 259-319. 

Professor and Head, Laboratory of Functional and Metabolic Imaging Professor, Department of Radiology,... 

Figure 2.6 illustrates stunned myocardium with normal resting perfusion but a severe stress induced perfusion defect that indicates severe ischemia in the distribution of the RCA and the LAD proximal to the first septal perforator. Metabolic imaging with FDG is not necessary, since resting perfusion is normal without scar with a left ventricular ejection fraction (LVEF) of 30% thereby indicating stunned myocardium that normalized after bypass surgery. This patient with severe stress induced ischemia and reduced LV function characteristic of stunned myocardium contrasts with the patient of Fig. 2.2 with severe ischemia but normal LV function and no stunning. 

The value of PET for predicting contractile function after revascularization depends on whether perfusion or metabolic imaging is performed, or both. For perfusion imaging alone, if regional blood flow is preserved to more than 50% of normal, contractile dysfunction will likely recover with an average positive and negative predictive value of 63% (range... 

Di Carli MF, Davidson M, Little R, Khanna S, Mody FV, Brunken RC et al. Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction. Am J Cardiol 1994 73 527-533... 

Schooner H, Campos R, Outtake T, Hoh CK, Moon DH, Czerny J et al. Blood flow-metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction. J Am Coll Cardiol 1999 33 1328-1337... 

C.S. Brock, S.R. Meikle, P. Price, Does fluorine-18 fluorodeoxyglucose metabolic imaging of tumors benefit oncology Eur. J. Nucl. Med. 24 (1997) 691-705. 

In 2001, Weber et al. [82] showed in a study cohort of 40 patients with locally advanced adenocarcinoma of the esophagogastric junction that prediction of histopathologic response is possible by metabolic imaging with [ F]-FDG as early as 2 weeks after induction of chemotherapy. Application of the criterion metabolic response—defined as a reduction of baseline SUV of more than 35%—allowed prediction of clinical response with a sensitivity of 93% and specificity of 95%, respectively (Fig. 2). 

K. Ott, U. Fink, K. Becker, A. Stahl, H.J. Dittler, R. Busch, H. Stein, F. Lordick, T. Link, M. Schwaiger, J.R. Siewert, W.A. Weber, Prediction of response to preoperative chemotherapy in gastric carcinoma by metabolic imaging Results of a prospective trial, J. Clin. Oncol. 21(24) (2003) 4604 610. 

The time course for biodistribution of a radiopharmaceutical throughout the body is a multifaceted function involving the rate of delivery of the tracer to individual tissues, the rate at which the tracer is extracted and retained by the tissues, and the rate at which the tracer is chemically processed, or for some reason egresses from the tissue. In metabolic imaging... 

The application of metabolic imaging assays of cerebral protein synthesis (CPS) shows that, despite... 

Golman K, Petersson JS. 2006b. Metabolic imaging and other applications of hyperpolarized 13cl. Acad Radiol 13 932-942. 

Golman K. In T Zandt, R. and Thaning, M. 2006a. Realtime metabolic imaging. Proc Natl Acad Sci USA 103 11270-11275. 

Both these 5-hydroxyindoles are natural compounds, playing an important role in the brain. 5-hydroxytryptophan (5-HTP) 315 is the metabolic precursor for the neurotransmitter serotonin melatonin 316 is a neurohormone involved in the regulation of chronobiological rhythms such as sleep and fertility306. They have been labelled with F-18, for in vivo metabolic imaging with PET, in reaction of dilute [18F]fluorine gas with melatonin or with 5-hydroxytryptophan in hydrogen fluoride307 at — 70 °C (equation 134). 

Levivier M., et al. The Integration of Metabolic Imaging in Stereotactic Procedures including Radiosurgery a Review. J Neurosurg.. 2002 Dec 97(5 Suppl) 542-50. 

Schelbert HR. Metabolic imaging to assess myocardial viability. J Nucl Med 1994 35(suppl) 8S-14S. 

In post-chemo brain there is a much less drastic effect on the tissues involved. Metabolic imaging exams show us that people exposed to chemotherapy have impaired brain function in certain regions compared to others who have not been exposed. But there is no sig-... 

Figure 14 (A) Planning images for magnetic resonance spectroscopy (MRS) of the brain top and middle spin-echo image TE = 96 ms, TR = 3 s. Bottom gradient echo image TE = 1.9 ms, TR = 116 ms. (B) Chemical shift metabolic image (CSI) of the brain overlaid on the anatomic image. Spectra are displayed for the selected regions. Chemical shift range is from 4.3 to 0.5 ppm. (Spectra were obtained by Dr JA Hopkins, GE Medical Systems and reproduced by permission of GE Medical Systems, Milwaukee, Wl.)...

Mueller-Klieser W, Walenta S, Paschen W, Kallinowski F, Vaupel P (1988) Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting. J Natl Cancer Inst 80 842-848... 

B. R. Masters, A. Krietc, J. Kukulies "Ultraviolet Confocal Fluorescence Microscopy of the In-Vitro Cornea Redox Metabolic Imaging, Applied Optics 32 (1993) no. 4,. 592-5%. 

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