Reser pine

Salim (1992d) has performed several studies using reser-pine to produce a chronic model of peptic ulceration in rats. Administration of allopurinol, DMSO, cysteine or methionine-S-methylsulphonium chloride protected against injury. In addition allopurinol and DMSO were found to stimulate healing in this model. In an acute model of duodenal ulceration induced by pentagastrin and carbachol allopurinol, DMSO, cysteine or methionine-S-methylsulphonium chloride all protected against injury. 

Kewitz H, Jesdinsky HJ, Shroter PM, et al. Reser-pine and breast cancer in West Germany. Eur J Clin Pharmacol 1977 11 79-83. 

Eriedman E, Wang H-Y Effect of chronic lithium treatment on 5-hyroxytryptamine autoreceptors and release of 5-[3H]hydroxytryptamine from rat brain cortical, hippocampal, and hypothalamic slices. J Neurochem 50 195-201, 1988 Eriedman E, Dallob A, Levine G The effect of long-term lithium treatment on reser-pine-induced supersensitivity in dopaminergic and serotonergic transmission. life Sci 25 1263-1266, 1979... 

Detection bias occurs in convenience-cohort studies when any measure of substance exposure is correlated with differences in medical scrutiny. For example, the positive relationship between reser-pine (a blood pressure medication) and breast cancer might be attributable to the fact that women under treatment for high blood pressure are more likely to have breast exams, which detect otherwise silent breast cancers (Feinstein 1988, 1261). The same might be true of the relationship between alcohol intake and breast cancer, because alcohol could be a surrogate for income and more frequent breast cancer screening and mammography (Feinstein 1988, 1261). 

Awang DVC, Dawson BA, Girard M, Vincent A, Ekiel I. The product of reser-pine autoxidation. J Org Chem 1990 55 4443-4448. 

Viloxazine, a bicyclic compound, is related structurally (but not pharmacologically) to the beta-adrenoceptor antagonists. In animal tests, its profile shows properties of both the imipramine-like compounds (reversal of reser-pine-induced hypothermia) and amphetamine (stimulation of the electroencephalogram). A review of animal and clinical data confirmed the impression that viloxazine has efficacy comparable to that of imipramine but with a different adverse effects profile (1). There is a reduced frequency of anticholinergic and sedative effects and a tendency to lose rather than to gain weight. However,... 

Asker AF, Helal MA, Motawi MM. Light stability of some parenteral solutions of reser-pine. Pharmazie 1970 26 90-92. 

Tricyclic antidepressants reverse the hypotensive effects of postganglionic blocking agents, guanethidine, reser-pine, clonidine, and alpha-methyldopa, and the addition of a tricyclic can result in loss of blood pressure control (159,179). Sudden withdrawal of a tricyclic compound from a patient stabilized with these compounds can also result in serious hypotension. An additional reason for avoiding drugs such as reserpine, methyldopa, and... 

Dick HLH, McCawley EL, and Fisher WA (1962) Reser-pine-digitalis toxicity. Archives of Internal Medicine 109 503-506. 

S,Cinchona alkaloids,brucine,strychnine, emetine.reser-pine. yohimbine, caffeine Detection with conductance detector Silica gel 10 pm CHC13-MeOH-hexane(7 3 10) 36... 

CAS 84-36-6. C35H42N2On. Methyl reserpate ester of syringic acid ethyl carbonate. An analog of reser-pine. 

Major depressive disorders have been postulated to arise from a functional deficiency in brain NE and/or 5HT (amine hypothesis of depression). This notion is largely based on the acute actions of antidepressant drugs (which may t NE and/or 5HT actions) and the fact that reser-pine (which depletes brain amines) causes depression. However, no antidepressant takes effect rapidly, and some drugs do not appear to have significant effects on brain amines. 

S.R. Varma, J.M. Calatayud, H.A. Mottola, Continuous-flow determination of reser-pine by oxidation with periodate ion and catalysis by manganese(II) in solution or by an Mn02(s) reactor, Anal. Chim. Acta 233 (1990) 235. 

The model scheme (Figure 18) developed by Iversen illustrates some of the theories which have been advanced to explain the action of the tricyclic antidepressant and antipsychotic drugs, as well as that of reser-pine, amphetamine, and the false neurotransmitters. 

Nortriptyline may decrease hypotensive effects of centrally acting antihypertensive drugs, such as guanethidine, guanabenz, guanadrel, clonidine, methyldopa, and reser-pine. Concomitant use with disulfiram or ethchlorvynol may cause delirium and tachycardia. 

Prolactin-producing hypophyseal adenoma (prolactinoma) is the most common functional pituitary adenoma. Its prevalence peaks in women between 20 and 30 years of age. Hyperprolactinemia can be a cause of infertility and is associated with diminished gonadotropin secretion, secondary amenorrhea, and galactorrhea. The patient should first be examined for drug-induced hyperprolactinemia before any infertility work-up is initiated. For example, antidepressants, cimetidine, dopamine antagonists, reser-pine, sulpiride, verapamil, methyldopa, and estrogen therapy are known to interface with prolactin secretion. 

Apparently successful attempts have been reported in correlating vitro rates of solution with some measure of the bio-availad)ility of topical steroids , aspirin , reser-pine °, salicylamide and aminorex. No such correlation existed for l-isopropyl-l,2,3,4-tetrahydro-3-carboline. ... 

Andersen PH, Geisler A, Klysner R 1984 No change in rat cerebral cortex calmodulin content following chronic treatment with lithium, reserpine, imipramine, and lithium combined with reser-pine or imipramine. Acta Pharmacol Toxicol 54 394-399... 

The next stage of the synthesis required introduction of the indolylethyl group and oxidative cyclization to afford the pentacyclic skeleton of reser-pine. First the carbamate was removed from decahydroisoquinoline 133 to give 134. Alkylation then gave 135. The next task was oxidative cyclization to provide the pentacyclic indole skeleton. At this point it becomes clear why loss of the enamide was unfortunate. 

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