Alpha methyldopa

GL Amidon, AE Merfeld, JB Dressman. Concentration and pH dependency of alpha-methyldopa absorption in rat intestine. J Pharm Pharmacol 38 363-368, 1986. 

Hu Ming, HI Mosberg, GL Amidon. Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa Carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa. Pharm Res 6(1) 66—69, 1989. 

M Asgharnejad, GL Amidon. Improved oral delivery via the peptide transporter A dipeptide prodmg of L-alpha-methyldopa. Pharm Res 9 S-248, 1992. 

Hu, M. and R. Borchardt. Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2)., Pharm. Res. 1990, 7, 1313-1319... 

Worlledge, S.M., Carstairs, K.C., and Dacie, J.V., Autoimmune haemolytic anaemia associated with alpha-methyldopa therapy, Lancet 288, 135, 1966. 

Antihypertensive Alpha methyldopa Clonidine Guanethidine Propranolol Reserpine... 

Other medications, which will not be discussed in the following chapters, have psychotropic actions that are considered to be side effects or adverse effects. Thus, some antihistamines (Le. products used to counteract allergic reactions) induce fatigue and drowsiness, and the same applies to some myorelaxants. Older antihypertensives (Le. agents reducing blood pressure) such as alpha-methyldopa (Aldomet ) or clonidine (Catapres 1) can cause fatigue and depression. 

M. Shimohira, J. Kohyama, Y. Kawano, H. Suzuki, M. Ogiso and Y. Iwakawa, Effect of alpha-methyldopa administration during pregnancy on the development of a child s sleep, Brain Dev., 8 (1986) 416-423. 

S. De Boer, M. Mirmiran, F. Van Haaren, A.L. Louwerse and N.E. Van de Poll, Neurobehavioral teratogenic effects of clomipramine and alpha-methyldopa, (submitted). 

Rapid exacerbation (1-21 days) or delayed (3-38 months) de novo appearance of immune hemolytic anemia has been reported after initiation of interferon alfa treatment in nine patients with lymphoproliferative disorders (220). However, this rare event was identified in only 1% of 581 patients receiving interferon alfa alone or as part of a chemotherapeutic regimen for chronic myelogenous leukemia (221). A mechanism close to that observed with alpha-methyldopa has been thought to be involved (208). The direct antiglobulin test was positive in 32% of 28 chronic myeloid leukemia patients after a median of 1 year of treatment with interferon alfa (222). 

Arranto AJ, Sotaniemi EA. Morphologic alterations in patients with alpha-methyldopa-induced liver damage after short- and long-term exposure. Scand J Gastroenterol 1981 16(7) 853-63. 

---