References—continued patents

The Minitran system, by 3M Health Care, is a monolithic transdermal system that deUvers nitroglycerin at a continuous rate of 0.03 mg/(cm h) (81). The dmg flux through the skin is higher than the previous two systems thus the Minitran system is a smaller size for equivalent dosing. For example, the 0.1 mg/h dose is achieved with a 3.3 cm system rather than the 5 cm systems of Transderm-Nitro or Nitro-dur. Because the skin is rate-controlling in a monolithic system and the Minitran flux is higher than the similar monolithic Nitro-dur system flux, it appears that 3M Health Care has included an additive to increase the skin flux to 0.03 mg/(cm h). Whereas this information is not apparent in Reference 81, patent information supports the hypothesis (96). 

A continuation patent is one filed during the pendency of another, earlier patent application, which contains the same disclosure as the earlier application. The continuation refers back to the earlier application and receives the benefit of its earlier filing date for purposes of identifying prior art and determining patentability. 35 U.S.C. 120 Transco Prods., Inc. v. Performance Contr., Inc., 38 F.3d 551, 555-56 (Fed. Cir. 1994). 

The literature before 1967 is included retrospectively in the database CAOLD, which, in the meantime, contains 700,000 references to 1.4 million substances, which were mentioned before 1967, and 152.000 references to patents. For this database Chemical Abstracts Service scans bit by bit the Formula Index of the Sixth (1957-1961) and the Seventh (1962-1966) Collective Period. Therefore only substance references are contained in this database with no text information or even abstracts. However, cross-references to patents are marked with P. Using this database you have to consider that the chemical nomenclature in those days was quite different to the names in use today. Therefore an online search in CAOLD should be proceded by a search in the Registry File (Sect. 7.6) and then continued with the appropriate CAS Registry Number in CAOLD. 

We should not minimize the effects that electronic searching of patents has had on the business of research. In 1990, CAS introduced MARPAT, which is a database of Markush (generic) structures found in patent documents [1]. This database provided a valuable tool for patent searching in a more comprehensive way than had been available previously. In 1995, CAS launched SciFinder, which provided access to the patent literature for chemists on their desktops. Using the SciFinder interface, one may search for research topics, authors, companies, or structures/reactions. From a practical viewpoint, SciFinder did more to enhance the searching capabilities of the medicinal chemist than any other tool. Even today, SciFinder continues to provide a first pass through the patent literature when chemists want to include patents in their searching. Indeed, when a search is performed, patent references are included in the answer set. Only very recently have there been additional tools to search the patent literature that have found widespread use. 

Instead of a theory to elucidate the important unsolved problems of chemistry, theoretical chemistry has become synonymous with what is also known as Quantum Chemistry. This discipline has patently failed to have any impact on the progress of mainstream chemistry. A new edition of the world s leading Physical Chemistry textbook [4] was published in the year that the Nobel prize was awarded to two quantum chemists, without mentioning either the subject of their work, nor the names of the laureates. Nevertheless, the teaching of chemistry, especially at the introductory level, continues in terms of handwaiving by reference to the same quantum chemistry, that never penetrates the surface of advanced quantum theory. 

The rearrangement reaction continues to be of synthetic utility, often involved in industrial processes. Patent references (e.g. Reference 48) refer to the formation of 4-amino phenols. Often the reactant nitro compound is reduced (to the hydroxylamine) in an acid environment so that the two-stage reaction can be accomplished as a one-pot synthesis. 4-Amino phenol itself 45 can be made in high yield directly from nitrobenzene49 and the 4-methoxy aniline derivative 46 similarly from 2-methylnitrobenzene by hydrogenation in MeOH/H2S0450. 

The search for new initiators continues past the metallocenes. There is always the desire to produce polymers with different structures in a controlled manner hy selective choice of the initiator. New initiators might produce polymers with structures different from those obtained by the metallocenes, such as branched instead of unbranched structures or different stereoregularity or different molecular weight. Finally, commerical interests require a continuing search for new initiators that have not yet been patented. Several of the newer classes of stereoselective initiators are described below. They are referred to here by the general terms postmetallocene or chelate initiators. 

Molybdenum comprises usually 50% or a little more of the total metallic elements. Most of molybdenum atoms form (Mo04)2 anion and make metal molybdates with other metallic elements. Sometimes a little more than the stoichiometric amount of molybdenum to form metal molybdate is included, forming free molybdenum trioxide. Since small amounts of molybdenum are sublimed continuously from the catalyst system under the working conditions, free molybdenum trioxide is important in supplying the molybdenum element to the active catalyst system, especially in the industrial catalyst system. In contrast, bismuth occupies a smaller proportion, forming bismuth molybdates for the active site of the reaction, and too much bismuth decreases catalytic activity somewhat. The roles of alkali metal and two other additives are very complicated. Unfortunately, few reports refer to these elements, except patents. In this article, discussion is directed only at the fundamental structure of the multicomponent bismuth molybdate catalyst system with multiphase in the following paragraphs. 

In the patent referred to above, the cell described is suitable for the electrolysis of alkali chloride and is of the bell type, but it is particularly suitable for electrolysing alkali nitrate. Pure nitric acid is formed at the anode inside the bell and is removed by distillation, which is effected by working under reduced pressure and by heating the bells with superheated steam. The nitrite which is formed at the cathode is drawn off continuously and separated outside the cell. The cell itself acts as cathode, and the anode is of such size as to almost dll the bell and thus reduce the working space of the eleotrolyte. High current density (16 amps, per dm.8), reduced pressure and high temperature, are favourable to the distillation of a large amount of concentrated nitric acid. 

Continuous screw presses are used (1) for extracting fats and oils in small operations where investment capital or supplies of raw materials are limited and installation of a solvent extraction plant is impractical (2) to partially defat high-oil content seeds for easier handling in subsequent solvent extraction or hard pressing and (3) for extraction of animal flesh and bones, fish, and fleshy-type oilseeds such as palm fruit, olives, and copra (dried coconut meat ), and oilseeds. These machines have been generically referred to as expellers, but the Expeller trademark belongs to Anderson International Corporation, Cleveland, OH, successor to the company founded by Valerius D. Anderson who patented the first continuous screw press in 1899. 

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