Receptors, molecular

W16. Wimalawansa, S. J Calcintonin gene-related peptide and its receptors Molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr. Rev. 17,533-585 (1996). 

Gall, C. von, Stehle, J. H. Weaver, D. R. (2002). Mammalian melatonin receptors molecular biology and signal transduction. Cell Tiss. Res. 309, 151-62. 

Ochoa, E., Chattopadhyay, A., McNamee, M. Desensitization of the nicotinic acetylcholine receptor Molecular mechanisms and effect of modulators. Cell Mol. Neurobiol. 9 141, 1989. 

Bernard, D.J. Chapman, S.C., and Woodruff, T.K. 2002. Minireview inhibin binding protein (InhBP/pl20), betaglycan and the continuing search for the inhibin receptor. Molecular Endocrinology 16(2), 207-212. 

On the model of the receptors in the bioinformation networks, several types of molecular assemblies may be designed for molecular information transduction. The molecular assembly should contain at least one receptor molecular component that can recognize selectively a specific molecular information. The receptor component responds to a specific molecular information in changing in conformation and electron transfer, which results in information transduction as schematically shown in Fig.4. 

The peculiar features of the three arAR supermolecules were translated into pharmacophore hypotheses by means of Catalyst software (Figure 8.2, unpublished results). Catalyst treats molecular structures as templates placing chemical functions in 3D space to interact with the receptor. Molecular flexibility is taken into account by considering each compound as a collection of conformers representing different areas of the molecules conformational space within a given energy range. 

Rosenfeld, J.M., Vargas, R., Jr, Xie, W. and Evans, R.M. (2003) Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Molecular Endocrinology, 17, 1268-1282. 

Eukaryotic ABC transport system Phosphotransferase system (PTS) Ion-coupled transport system Signal Transduction Two-component system Bacterial chemotaxis MAPK signaling pathway Second messenger signaling pathway Ligand-Receptor Interaction G-protein-coupled receptors Ion-channel-linked receptors Cytokine receptors Molecular Assembly Ribosome assembly Flagellar assembly Enzyme assembly... 

Kristiansen K. Molecular mechanisms of ligand binding, signalling, and regulation within the superfamily of G-protein-coupled receptors molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther 2004 103 21-80. 

Hart BR, Shea KJ. Synthetic peptide receptors molecularly imprinted polymers for the recognition of peptides using peptide-metal interactions. J Am Chem Soc 2001 123 2072-2073. 

Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators... 

ER-Luc Estrogenic compounds activation Estrogen receptor molecular, indicative of chronic physiological effects 17 3-estradiol, xenoestrogens 6.8 ng EEQ/kg, 5 - 15%, Natural estrogenic compounds nd... 

Meunier J, Mouledous L, Topham CM The nociceptin (ORL1) receptor Molecular cloning and functional architecture. Peptides 2000 21 893. [PMID 10998522]... 

Quock RM et al The delta-opioid receptor Molecular pharmacology, signal transduction, and the determination of drug efficacy. Pharmacol Rev 1999 51 503. [PMID 10471416]... 

Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakman, B., Seeburg, P. H. Heteromeric NMDA receptors molecular and functional distinction of subtypes, Science 1992, 256, 1217-1221. 

Wroblewski, J. T. and Danysz, W. Modulation of glutamate receptors molecular mechanisms and functional implications, Annu. Rev. Pharmacol. Toxicol. 1989, 29, 441-474. 

Varying the side groups X in 27b affects both the stability and selectivity of the complexes (lateral discrimination), and allows the receptor-substrate interactions in biological systems to be modelled, for instance, the interaction between nicotinamide and tryptophan [2.109b]. One may attach to 27b amino acid residues (leading to parallel peptides [2.109] as in 27c), nucleic acid bases or nucleosides, saccharides, etc. The structural features of 27 and its remarkable binding properties make it an attractive unit for the construction of macropolycyclic multisite receptors, molecular catalysts, and carriers for membrane transport. Such extensions require sepa-... 

Keywords Artificial receptors Molecularly imprinted polymers Plastic antibodies Protein imprinting Water compatible MIP Controlled/living radical polymerization... 

Shoemaker, C.B., Ramachandran, H., Landa, A., Mitermayer, G.R. and Stein, L.D. (1 992) Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor. Molecular and Biochemical Parasitology 53, 1 7-32. 

Wess, J. (1997). G-protein-coupled receptors Molecular mechanisms involved in receptor activation and selectivity of G-protein recognition. FASEB J. 11, 346-354. Wess, J. (1998). Molecular basis of receptor/G-protein-coupling selectivity. Pharmacol. 

Buckbinder L, Robinson RP. The glucocorticoid receptor molecular mechanism and new therapeutic opportunities. Curr Drue Targets Inflamm Allergy. 2002 1 127-136. 

Wipff, G., Wurtz, J. M. (1988) Dynamics Views of Macrocyclic Receptors Molecular Dynamics Simulations and Normal Modes Analysis, in Pullman, R. (eds.), Transport through Membranes, Carriers, Channels and Pumps, Reidel, Dorbrecht, pp 1-26. 

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