Channel-linked receptors

Eukaryotic ABC transport system Phosphotransferase system (PTS) Ion-coupled transport system Signal Transduction Two-component system Bacterial chemotaxis MAPK signaling pathway Second messenger signaling pathway Ligand-Receptor Interaction G-protein-coupled receptors Ion-channel-linked receptors Cytokine receptors Molecular Assembly Ribosome assembly Flagellar assembly Enzyme assembly... 

Studies on molecular recognition by artificial receptors are thus one of the most important approaches to such characterization in relation to supramolecular chemistry [4]. Functional simulation of intracellular receptors in aqueous media has been actively carried out with attention to various noncovalent host-guest interactions, such as hydrophobic, electrostatic, hydrogen-bonding, charge-transfer, and van der Waals modes [5-10]. On the other hand, molecular recognition by artificial cell-surface receptors embedded in supramolecular assemblies has been scarcely studied up to the present time, except for channel-linked receptors [11-13]. 

Salty apparently perceived by an ion-channel-linked receptor... 

Receptors can be broadly sorted into superfamilies based on their structure and mode of action. The membrane-bound receptor superfamilies are G-protein-coupled, kinase-linked, and ion channel-linked receptors. Superfamilies are divided into families named after the natural, or endogenous, ligand that binds all the members of a given family. Unnatural, or exogenous, ligands can show selectivity for specific receptors within a family and allow further subdivision.2... 

Most receptors are protein macromolecules. When the agonist binds to the receptor, the proteins undergo an alteration in conformation which induces changes in systems within the cell that in turn bring about the response to the drug. Different types of effector-response exist. (1) The most swift are the channel-linked receptors, i.e. receptors coupled directly to membrane ion channels neurotransmitters... 

I Ion channel-linked receptors are protein structures containing about 20 transmembrane segments (i.e. they cross the cell membrane 20 times) so arranged to form a central channel. 

Recent investigations by a number of research groups have disclosed that, in addition to ion channel-linked receptors mediating fast depolarizing... 

Benzodiazepines facilitate inhibition by y-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. The benzodiazepine receptor is a subtype of the GABA receptor. Activation of the benzodiazepine receptor facilitates the action of endogenous GABA, which results in the opening of chloride ion channels and a decrease in neuronal excitability. Benzodiazepines act rapidly because ion channels can open and close relatively quickly, in contrast to the slower onset of action that occurs with G protein-linked receptors. 

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