Recognition proteins

Brennan, R.G., Matthews, B.W. Structural basis of DNA-protein recognition. Trends Biochem. Set. 

Ohlendorf, D.H., et al. The molecular basis of DNA-protein recognition inferred from the structure of Cro repressor. Nature 298 718-723, 1982. 

The world of zinc-containing DNA-binding proteins is by no means exhausted by these three subfamilies. Several other subfamilies are already known with different three-dimensional structures and different sequence patterns of cysteine and histidine residues that form the zinc ligands. Further subfamilies may well be discovered as the genomes of different species are sequenced whether or not any fundamentally new principles for DNA-protein recognition will be discovered amongst these new subfamilies remains to be seen. 

In light of the importance of the / -turn motif in peptide and protein recognition, and the design and synthesis of bioactive small molecules, / -turn mimetics has attracted considerable attention. Seebach and coworkers have shown recently that low molecular weight open-chain / - and y-peptides designed to promote turn formation can be used as templates for mimicking the a-peptide hormone somatostatin. 

Zeng, Jun Fridman, M. Maruta, FI. Treutlein, Flerbert R. Simonson, T., Protein-protein recognition an experimental and computational study of the R89K mutation in Raf and its effect on Ras binding, Prot. Set 1999, 8, 50-64. 

Protein recognition p53 activation cell cycle control... 

An illustrative example of carbohydrate-protein recognition has been reported by Chen and coworkers [192] using a C18-mucin mimic polymer that interacts hydro-phobically with SWCNTs. This biohybrid is able to specifically recognize the lectin Hdixpomatia agglutinin (Figure 1.15 A). Galactose-modified CNTs are able to capture... 

The unwinding of the helix at the site of platination is 25°. The curvature and shape of the platinated duplex are remarkably similar to those observed in DNA duplexes complexed by the HMG-domain proteins revealing that cisplatin binding alters DNA in such a manner as to facilitate HMG-domain protein recognition as mentioned in the previous paragraph. 

Fanelli, F., Menziani, C Scheer, A., Cotecchia, S., and DeBenedetti, R G. (1999) Theoretical study on receptor-G protein recognition new insights into the mechanism of the au,-adrenergic receptor activation. Inti. J. Quant. Chem. 73,71-83. 

Lo Conte, L., Chothia, C and Janin, J. (1999) The atomic structure of protein-protein recognition sites../. Mol. Biol. 285,2177-2198. 

Kobe, B., and Kajava, A. V. (2001). The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 11, 725-732. 

The term homology domain or functional domain should be used only for those protein regions that either are known to be domains in the structural sense or that are at least predicted to fulfil that condition. Conserved sequence regions that are too short to fold independently of the rest of the protein should rather be referred to as motifs . A considerable number of those functional motifs have important roles, e.g. by being responsible for specific domain- or protein-recognition events. 

In the synthesis of peptides and proteins, recognition of the constituent aminoacids is almost immediate however, the realisation of the synthesis in the laboratory may be one of the most arduous tasks which the synthetic organic chemist faces. The molecular magnitude and the strong polarity which tends to make the reaction intermediates very insoluble, as well as the problem of conservation of... 

Baltzer L (2007) Polypeptide Conjugate Binders for Protein Recognition. 277 89-106... 

Jurica MS, Stoddard BE. 1998. Mind your B s and R s bacterial chemotaxis, signal transduction and protein recognition. Structure 6 809-13. 

Dunham, S.U. and Lippard, S.J. (1997) DNA sequence context and protein composition modulate HMG-domain protein recognition of cisplatin-modified DNA. Biochemistry 36, 11428-11436. 

Forman-Kay, J. D., and Pawson, T. (1999). Diversity in protein recognition by PTB domains, Curr Opin Struct Biol 9,690-5. 

The chromatic transition was completely blocked by a-methyl sialoside, a soluble competitive inhibitor of the influenza virus, demonstrating that binding of the virus to the film was due to a specific carbohydrate-protein recognition event. This experiment demonstrated that the chromatic transition of the PDA backbone could be triggered by molecular recognition of a membrane surface ligand that was covalently attached to the polymerized lipid. 

Bossi A, Piletsky SA, Piletska EV, Righetti PG, Turner AP. Surface-grafted molecularly imprinted polymers for protein recognition. Anal Chem 2001 73 5281-5286. 

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