Imprints of Proteins

Hansen DE, Recent developments in the molecular imprinting of proteins, Biomaterials, 2007, 28, 4178-4191. 

A year later the same research group presented a second rather different approach [160] in which they described the production of abiotic receptors by imprinting of proteins. The basic idea was once again to induce a certain conformation into the tertiary structure of a protein using a template and then to freeze it in . Bovine serum albumin (BSA) was dissolved in water, containing either p-hydroxybenzoic acid or tartaric acid. After lyophilisation the protein was washed with anhydrous solvent to remove the template. The resultant imprinted proteins bound up to 30-fold more of the template in anhydrous... 

Fig. 6.6. Schematic illustration of molecular imprinting of proteins on the surface of a metal-coordinating bilayer assembly.

Dabulis, K. and Klibanov, A. M., Molecular imprinting of proteins and other macromolecules resulting in new adsorbents, Biotechnol. Bioeng., 39, 176-185, 1992. 

Fig. 23 a Schematic illustration of molecular imprinting of proteins on the surface of a metal-coordinating bilayer assembly (adapted from [87]). b Synthetic procedure for Cu(II) imprinted microspheres (adapted from [37,124])... 

Braco, L. Dabulis, K. Klibanov, A.M. Production of abiotic receptors by molecular imprinting of proteins. Proc. Natl. Acad. Sci. USA 1990, 87, 274-277. 

Figure 20 Principle of affinity imprinting of proteins shown for the imprinting of trypsin using a polymerizable p-aminobenzamidine affinity ligand. (Reproduced from Ref. 49. Wiley Periodicals, Inc, 2001.)...

Takeuchi, T. and Hishiya, T. (2008) Molecular imprinting of proteins emerging as a tool for protein recognition . Organic Biomolecular Chemistry, 6,2459-2467. 

Verheyen E, Schillemans JP, van Wijk M, Demeniex M-A, Hennink WE, van Nostrum CF (2011) Challenges for the effective molecular imprinting of proteins. Biomaterials 32... 

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