Receptor structure

Wilson, I.A., Garcia, K.C. T-cell receptor structure and TCR complexes. Curr. Opin. Struct. Biol. 7 839-848, 1997. 

These first-created enantiophores are rudimentary, but may serve as useful guidelines for a further design of more sophisticated and efficient search queries in consideration of possible alternative modes of binding and conformational changes in the CSP receptor structure. Undoubtedly, this query optimization will soon take advantage of the backgrounds of our new 3D-database project called CHIR-SOURCE. 

More complex models must carefully consider additional factors such as the receptor structure of helper T cells and allow for, what in reality, is a less than perfect lock and key match between antibody and antigen. For the latter case, Stauffer [staufF92] describes two schemes in which more than one type of antibody fits a given antigen and more than one type of antigen corresponds to a given antibody. 

Kobilka BKG (2006) G protein coupled receptor structure and activation. Biochim Biophys Acta... 

Jensen AA, Frolund B, Liljefors T et al (2005) Neuronal nicotinic acetylcholine receptors structural revelations, target identifications, and therapeutic inspirations. J Med Chem 48 4705—4745... 

Nothacker HP, Reinscheid, RK, Civelli O (2001) From receptor to ligand. In Stanford C, Horton R (eds) Receptors Structure and function. CRC press, Oxford pp. 41-63... 

Almeida TA, Rojo J, Nieto PM et al (2004) Tachykinin and tachykinin receptors structure activity relationships. Curr MedChem 11 2045-2081... 

It is interesting that the stimulus compounds used in the study differ widely in their molecular structures, and yet they all interact with antibodies to thaumatin. It is, therefore, probable that a single receptor-structure responds to all sweet stimuli,there being a variation in the relative effectiveness of sweet stimuli across individual nerve-fibers, and the characteristics of all receptor sites do not appear to be identical. Earlier elec-trophysiological studies of single primary, afferent taste-neurons uniformly agreed that individual fibers very often have multiple sensitivities, and that individual, gustatory receptors are part of the receptive field of more than one afferent fiber. " We have yet to learn how these interact, and the nature of their excitatory, or possible inhibitory, relations, or both. 

Ajami K, Pitman MR, Wilson CH et al (2008) Stromal cell-derived factors lalpha and Ibeta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Lett 582 819-825 Albright AV, Shieh JT, O Connor Ml et al (2000) Characterization of cultured microglia that can be infected by HIV-1. J Neurovirol 6(Suppl 1) S53-S60 Allen SJ, Crown SE, Handel TM (2007) Chemokine receptor structure, interactions, and antagonism. Annu Rev Immunol 25 787-820... 

The following sections of this chapter will consider some general and comparative aspects of receptor structure and function. More detailed material on these topics may be found in the relevant chapters on individual neurotransmitters. 

Neurotransmitter receptors have evolved as one of the key components in the ability of the central nervous system to coordinate the behaviour of the whole animal, to process and respond to sensory input, and to adapt to change in the environment. These same receptors are therefore ideal targets for drug action because of their central role in the activity of the nervous system. A rational approach to the development of new therapeutic strategies involving the action of drugs at receptors in the nervous system is based on knowledge of receptor structure, distribution and function. 

Changeux, JP, Bertrand, D, Corringer, PJ, Dehoene, S, Edelstein, S, Leno, C, Novere, N le, Marubio, L, Picciotto, M and Zoli, M (1998) Brain nicotinic receptors structure and regulation, role in learning and reinforcement. Brain Res. Rev. 26 198-216. 

Leeson PD, Iversen LL (1994) The glycine site on the NMDA receptor structure-activity relationships and therapeutic potential. J Med Chem 37(24) 4053-4067... 

Stroud, R. M., and J. Tinner-Moore, Acetylcholine receptor, structure, formation and evolution, Ann. Rev. Cell Biol., 1, 317 (1985). 

FURTHER READING Rhodopsin-like 7TM receptor structure... 

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