Quick*Risk

Administer PCN IV slowly. Penicillin contains potassium. Administering PCN IV quickly risk heart failure if the patient has renal insufficiency. 

Screening with QUICK RISK. For users who need to set assessment priorities for a large number of sites, QUICK RISK provides a means to accomplish the task rapidly. The user need only specify probable contaminant concentrations in environmental media, and QUICK RISK applies appropriately conservative exposure assumptions. Although only one scenario is considered for any medium, further detail is probably not needed for the initial selection of site priorities, and QUICK RISK provides for consistent evaluation. Assuming that concentration estimates were available, several hundred sites could be evaluated in a single day. 

QUICK RISK also provides users with the ability to respond quickly to requests for risk information regarding poorly characterized situations. For example, a telephone inquiry about potential risks associated with water contamination could be answered in a matter of seconds. 

A quick risk taker X A slow risk taker... 

It is prudent that a few terms associated with PHA, mainly for PSM systems, are discussed. In Table II/2.1.2-1, a few hazard analysis methods have been highlighted such as the Dow FEI and the Mond Index, etc. for quick risk assessment in process plants. 

The contractor is paid per foot drilled. Whilst this will provide an incentive to make hole quickly, the same risks are involved as in the turnkey contract. Footage contracts are often used for the section above the prospective reservoir where hole conditions are less crucial from an evaluation or production point of view. 

Unstayed flat heads and covers can be designed by very specific rules and formulas given in this subsection. The stresses caused by pressure on these members are bending stresses, and the formulas include an allowance for additional edge moments induced when the head, cover, or blind flange is attached By bolts. Rules are provided for quick-opening closures because of the risk of incomplete attachment or opening while the vessel is pressurized. Rules for braced and stayed surfaces are also provided. 

A material that has a high toxicity does not necessarily present a severe toxic hazard. For example, a ton of lead arsenate spilled in a busy street is unhkely to poison members of the public just a short distance from the spiU, because it is not mobile. It could be carefully recovered and removed and would present a low risk to the gener pubhc, even though it is extremely toxic. On the other hand, a ton of liquefied chlorine spilled on the same street could become about 11,000 fF of pure gas. The IDLH for chlorine is 25 ppm. This is a concentration such that immediate action is required. Thus, the one ton of chlorine, if mixed uniformly with air, could create a cloud of considerable concern, having a volume of about 4.4 X 10 fF or a sphere 770 ft in diameter. This could quickly spread over downwind areas and... 

Whilst the hazards identified, and the principles and practice for the control of risks are universal, i.e. they are independent of location, in order to assist quick-reference an appendix of relevant contemporaneous UK legislation has been added as a guide together with a much-expanded Bibliography in Chapter 19. Finally, for convenience of use, the Index has been enlarged. 

Make sure to pay a visit to the Agency for Toxic Substances and Disease Registry (ATSDR). You can perform quick searches by clicking onto the first letter of a chemical listed. The web-site address is the following http //atsdr 1.atsdr.cdc.gov 8080/toxfaq.html. This site also provides some links to other sites with chemical specific information and health risk data. 

To produce this kind of grid map by quickly measuring the concentrations at some points for immediate processing and graphical presentation is a simple and often effective way to communicate the results to persons w ho are not trained to analyze primary results of measurements. The method must, however, be used with care since there is a risk that the sampling of data itself may affect the airflow in the studied area. I he equipment needed is relatively expensive, and the method is therefore of interest when the prerequisites are already available for other reasons. 

The detail plan for each audit may include dates if it is to cover several days but the main substance of the plan will be what is to be audited, against what requirements, and by whom. At the detail level, the specific requirements to be checked should be identified based upon risks, past performance, and when it was last checked. Overall plans are best presented as program charts and detail plans as checklists. Audit planning should not be taken lightly. Audits require effort from auditees as well as the auditor so a well-planned audit designed to discover pertinent facts quickly is far better than a rambling audit which jumps from area to area looking at this or that without any obvious direction. 

Remember as you set priorities that you and your team must consider the expected benefit to the company, division, or unit as a whole, rather than simply addressing a single gap. Obviously, any specific immediate risk you identify in the course of your assessment must be dealt with quickly and responsibly however, be careful not to let anomalous findings skew your perspective on broader priorities. For example, the absence of a capital project review process is a significant gap. However, if there is only one project per year this gap may have lower priority than an existing but seriously deficient operator training program. 

Products manufactured using concepts in UL Standard 746D provide quick verification of material identification, along with the assurance that acceptable blending or simple compounding operations are used that would not increase the risk of fire, electrical shock, or personal injury. 

XR D-5 D/S. As the goniometer circle is horizontal, the table (Figure 9-5) can carry a fairly heavy load of instruments, samples, or accessories without risk of distorting the goniometer angle. Any value of 26 can be set reliably and quickly. Good performance is available at widely... 

The risk of respiratory depression is a concern for many nurses administering a narcotic and may cause some nurses to hesitate to administer the drug. However, respiratory depression rarely occurs in patients using a narcotic for pain. In fact, these patients usually develop tolerance to the respiratory depressant effects of the drug very quickly. Naloxone (see Chap. 20) can be administered to reverse the narcotic effects if absolutely necessary. 

Tables (3-1, 3-2, and 3-3) and figures (3-1 and 3-2) are used to summarize health effects and illustrate graphically levels of exposure associated with those effects. These levels cover health effects observed at increasing dose concentrations and durations, differences in response by species, minimal risk levels (MRLs) to humans for noncancer end points, and EPA s estimated range associated with an upper- bound individual lifetime cancer risk of 1 in 10,000 to 1 in 10,000,000. Use the LSE tables and figures for a quick review of the health effects and to locate data for a specific exposure scenario. The LSE tables and figures should always be used in conjunction with the text. All entries in these tables and figures represent studies that provide reliable, quantitative estimates of No-Observed-Adverse-Effect Levels (NOAELs), Lowest-Observed-Adverse-Effect Levels (LOAELs), or Cancer Effect Levels (CELs).

Consequences While this may still appear reasonable, lower accepted impurity limits AIL quickly demand either very high m or then target levels TL below the LOQ, as is demonstrated in Fig. 4.7. If several impurities are involved, each with its own TL and AIL, the risk of at least one exceeding its AIL rapidly increases (joint probabilities, see Section 4.24). For k impurities, the risk is [1 - (1 - 0.05) ], that is for k = 13, every other batch would fail ... 

In a tiny fraction of cases, a quick formula can be used. For most cases, the analysis uses an options tree, with one leaf per possible outcome. However, this falls prey to the curse of dimensionality —the number of leaves on the tree grows exponentially in the number of risk and decision dimensions considered. Thus only a limited, simple set of situations can be optimized in this way because one has to severely limit the decisions and risks that are considered. Tools available to help automate and simplify options analysis, widely used in pharmaceutical project evaluation, include Excel addons such as R1SK [11] and more graphically based solutions such as DPL [12]. Both of these support the creation and evaluation of decision trees and of influence diagrams Figure 11.2 shows a simple example of each of these. A primer in applied decision theory is Clemen s book Making Hard Decisions, other sources may be found in the website of James Vornov, Director of Clinical Research at Guildford Pharmaceuticals, a recent convert to decision theory for options analysis [13]. 

---