Quadruplexes

Guyen B et al. (2004) Synthesis and evaluation of analogues of 10H-indolo[3,2-b] quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Org Biomol Chem 2(7) 981-988... [Pg.94]

Shi DF et al. (2001) Quadruplex-interactive agents as telomerase inhibitors synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J Med Chem 44(26) 4509-4523... [Pg.94]

Gavathiotis E et al. (2003) Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat. J Mol Biol 334(l) 25-36... [Pg.95]

Mergny JL et al. (2001) Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay. Proc Natl Acad Sci USA 98(6) 3062-3067... [Pg.95]

Riou JF et al. (2002) Cell senescence and telomere shortening induced by a new series of speciflc G-quadruplex DNA ligands. Proc Natl Acad Sci USA 99(5) 2672-2677... [Pg.95]

Kim MY et al. (2002) Telomestatin, a potent telomerase inhibitor that interacts quite speciflcally with the human telomeric intramolecular g-quadruplex. J Am Chem Soc 124(10) 2098-2099... [Pg.95]

Parkinson GN, Lee MP, Neidle S (2002) Crystal structure of parallel quadruplexes from human telomeric DNA. Nature 417(6891) 876-880... [Pg.95]

Haider SM, Parkinson GN, Neidle S (2003) Structime of a G-quadruplex-ligand complex. J Mol Biol 326(1) 117-125... [Pg.95]

Fedoroff OY et al. (1998) NMR-based model of a telomerase-inhibiting compoimd bound to G-quadruplex DNA. Biochemistry 37(36) 12367-12374... [Pg.95]

Protoberberine Alkaloid-Nucleic Acid Quadruplex Interaction. 196... [Pg.156]

Abstract Protoberberine alkaloids and related compounds represent an important class of molecules and have attracted recent attention for their various pharmacological activities. This chapter deals with the physicochemical properties of several isoquinoline alkaloids (berberine, palmatine and coralyne) and many of their derivatives under various environmental conditions. The interaction of these compounds with polymorphic DNA structures (B-form, Z-form, H -form, protonated form, triple helical form and quadruplex form) and polymorphic RNA structures (A-form, protonated form, triple helical form and quadruplex form) reported by several research groups, employing various analytical techniques such as spectrophotometry, spectrofluorimetry, circular dichro-ism, NMR spectroscopy, viscometry as well as molecular modelling and thermodynamic analysis to elucidate their mode and mechanism of action for structure-activity relationships, are also presented. [Pg.156]

Fig. 4 Schematic representation of parallel A and antiparallel B quadruplex form of DNA with the chemical structure of a G-tetrad C...

Fig. 4. Possible homo-dimers of psPtDNA (A) antiparallel duplex, (B) parallel duplex, (C) quadruplex. Adapted from Ref. (28).

Fig. 5. Possible base-pairing interactions for the quadruplex homodimer. Hoogsteen pairings of the parallel stranded PtDNA duplex requires protonation of the GC pair. Adapted from Ref. (28).

It has been suggested that zinc ions prevent formation of DNA quadruplexes containing guanine quartets by binding to the guanine N7 and 06. The quadruplexes are believed to be important to a number of areas of the genome including telomeres.179... [Pg.1159]

Self-Organization of the Guanine Quadruplex in Hybrid Supramolecular Polymers... [Pg.328]

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