G-DNA quadruplex

Riou JF et al. (2002) Cell senescence and telomere shortening induced by a new series of speciflc G-quadruplex DNA ligands. Proc Natl Acad Sci USA 99(5) 2672-2677... 

Fedoroff OY et al. (1998) NMR-based model of a telomerase-inhibiting compoimd bound to G-quadruplex DNA. Biochemistry 37(36) 12367-12374... 

Figure 9.11 G-quadruplex DNA. (From Wozki and Schmidt, 2002. Reproduced with permission from John Wiley Sons., Inc.)...

Figure 3.5 Disulfide-based dynamic combinatorial library selects for peptidic tiomodi-sulfide P-P and acridone-peptide heterodisulfide A-P G-quadruplex DNA ligands.

This relatively small DCL yielded the first peptidic ligand for G-quadruplex DNA, providing a lead compound for the further development of novel G-quadruplex ligands with possible therapeutic utility. 

Figure 3.7 Scaffold-centered DCL targeting G-quadruplex DNA (Nielsen and Ulven).

Whitney, A. M. Ladame, S. Balasubramanian, S. Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry. Angew. Chem. Int. Ed. 2004,43, 1143-1146. 

Han H, Hurley LH. 2000. G-quadruplex DNA a potential target for anti-cancer drug design. Trends Pharmacol. Sci. 21 136—42... 

Kerwin SM. 2000. G-Quadruplex DNA as a target for drug design. Curr. Pharm. Des. 6 441-78... 

T. Simonsson, G-quadruplex DNA structures - variations on a theme, Biol. Chem, 2001, 382, 621-628. 

K. Paeschke, T. Simonsson, J. Postberg, D. Rhodes and H.J. Lipps, Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo, Nat. Struct. Mol. Biol., 2005, 12, 847-854. 

M.J. Cocco, L.A. Hanakahi, M.D. Huber and N. Maizels, Specific interactions of distamycin with G-quadruplex DNA, Nucleic Acids Res., 2003, 31, 2944-2951. 

Figure 31 An optical sensor based on a complex formed between G-quadruplex DNA and a conjugated cationic polymer...

G-quadruplex DNA can convert to the duplex form in the presence of its complementary strand [82]. Such a conformational change can also be detected using P4 [83]. The overall strategy is illustrated in Scheme 1.18. The intercalator ethidium bromide (EB) is introduced into the assay solution. Electrostatic interactions between G-quadruplex-Fl and P4 keep them... 

Figure 27. Visualization of biomesogenic nucleic-acid selforganizations by molecular-resolving microscopies (top to bottom and left to right) nucleic acid strand patterns B-DNA and A-RNA duplexes, DNA/ RNA triplex, G-quadruplex, DNA/RNA-duplex/pro-tein-)3-sheet complexations STM and SFM-investi-gations of nucleic acid organizational behavior DNA-plasmid [74 c] RNA- and RNA/peptide-organiza-tions (U) (A) -duplexes (U) (A) (U) -tri-plexes (G) -quadruplexes, (L-Lys) /(U) (A) -com-plexes in 2D and 3D representation [7 a, 17, 18, 33 a, c, f, p, q, 75].

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