Hybrid supramolecular

Self-Organization of the Guanine Quadruplex in Hybrid Supramolecular Polymers... 

Hybrid supramolecular dynamic membranes as selective information transfer devices. Desalination, 199, 521-522. 

Nanoparticle and Biomolecular - Nanoparticle Hybrid Supramolecular Complexes for Electrochemical Signaling... 

Chapter 8 Nanoparticle and Biomolecular Nanoparticle Hybrid Supramolecular... 

An application of biomolecule-nanoparticle hybrid supramolecular assemblies is the sensitive detection of p53, a tumor suppressor protein, by AuNP streptavidin conjugates capped with multiple ferrocene molecules.26 As shown in Figure 8.6, a mixed monolayer of double-stranded DNA and 1-hexanethiol on an Au electrode is used to capture p53, which binds to DNA containing the consensus site sequence. Subsequent conjugation of the captured p53 with biotin allowed for attachment of... 

Roelfes, Feringa, and Kraemer (104,105) developed a similar hybrid supramolecular catalyst, which they named DNAzyme, relating to DNA as the biomacromolecular chiral host. 9-Aminoacridine-modified Cu(II) complexes were employed as metal fragments with high DNA affinities (Figure 29). The acridine unit is likely to intercalate into the double helix of the DNA. The Cu(II) catalytic center is thus brought into close proximity to the DNA, which creates a chiral environment around the Cu(II) site. Stereoinduction can be expected in any transformation mediated by this Cu(II) center. 

Cazacu A, Michau M, Arnal-Herault C, Pasc-Banu A, Meffre A, Caraballo R, Pasc A, Barboiu M. Hybrid supramolecular dynamic membranes as selective information transfer devices. Desalination 2006 199 521-522. 

Barboiu M. Hybrid supramolecular membranes as selective biomimetic transport devices. Proceedings of the Eight International Conference on Inorganic Membranes, Cincinnati, OH, July 18-22, 2004 159-162. 

Bu2)2Sn(2,5-PDC) 3] (2,5-PDC = 2,5-pyridinedicarboxylate, D = Lewis base, such as DMSO, H2O) and [ (n-Bu2)2Sn(l,3-BDC)(D) 3] (1,3-BDC = 1,3-benzenedicarboxylate) (Table 2.4.2, entries 4 and 6) deserve special mention. Both of these are macrocyclic compounds formed as a result of intermolecular bridging by the dicarboxylate ligands. Among these, [ (n-Bu2)2Sn(2,5-PDC) 3] forms a three-dimensional hybrid supramolecular network which traps hydrophobic molecules in its microporous channels. ... 

When the reactive chiral building unit [M(/ -(+)-BINAP)(H20)][0Tf]2 with M = Pd (5.84) or M = Pt (5.85) was treated with the bridging ligand bis [4-(4 -pyridyl)phenyl) iodonium triflate (57), the related chiral hybrid supramolecular squares were formed (5.86-5.87) (hybrid = presence of iodonium and transition metal comers in the assembly). These hybrid molecular squares are optically active due to the chiral transition metal auxiliary (BINAP) in the assembly. Interestingly chiral induction was observed in these metallo-macrocycles since the preferred diastereomer in each preparation was formed in excess compared with the other isomers (Figure 5.34). ... 

Formation of the chiral hybrid supramolecular squares (from reference ). 

A unique assembly of a crystalline hybrid supramolecular salt was achieved by reaction of 2,4-bis (3-pyridylmethyl)oxy -(l,3)-p-bu -calix[4]-crown-6 (33), hexadecafluoro-l,8-diidooctane and Csl (2(X) 4951). In its solid state, the cesium ion of the supercation was encapsulated inside the cavity created by the crown ether loop, the picolyl and inverted phenyl moieties, whereas the two iodide ions of the superanion, formed a discrete five component aggregate held together by hydrogen and halogen bonds. Similar adduct existed in solution. A combination of this calix-crown 33 and octafluoro-l,4-diiodobutane acted as an effective binary host for the selective extraction of Csl from aqueous to fluonous phase. 

Effects of remote chiral centers of the resorci-narene and cavitand ligand syntones on encapsulated guests have been observed in [127] for their hybrid supramolecular capsules 448-454 giving 1 1 cage complexes with encapsulated neutral guest 202 by Scheme 3.120. These distal effects are additive or subtractive, depending on the relative configurations of the chiral elements. 

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