Lipophilic quadruplex

Davis, J. T. Lipophilic G-quadruplexes are self-assembled ion pair receptors, and the bound anion modulates the kinetic stability of these complexes. J Am Chem Soc 2003, 125, 10830-10841. 

As mentioned above, hydrogen-bonded G ribbons can be converted to stacked cyclic G-quartets upon addition of a templating cation. To better understand the organization of these lipophilic G-quartets within higher ordered G-quadruplex structures, our group collaborated with Gottarelli s group to solve the NMR structure of [dG 3]g KI in CDCh. Remarkably, this discrete octamer... 

The bound cations in these lipophilic G-quadruplexes have been directly observed using solid-state NMR spectroscopy. Wu and colleagues used Na... 

Figure 7 Crystal structure shows that the cation-templated self-assembly of 16 equivalents of G 5 gives a lipophilic G-quadruplex [G 5]3K jCs 4Pic. This G-quadruplex is prepared quantitatively by extracting salts from water with a CHCI3 solution of G 5...

G. The sodium ions inside a lipophilic G-quadruplex channel as probed by solid-state Na NMR. J. Am. Chem. Soc. 21002. 124. 742-743. 

Figure 22 A lipophilic G-quadruplex that binds ion pairs. Pic, picrate R, 5 -silyl-2, 3 -isopropylidene-D-ribose. (Reproduced from Ref. 50. Wiley-VCH, 2001.)...

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