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Telomerase inhibitor

Very possibly, however, inhibitors for the previously mentioned enzymes may exist in the plant world, as distinguished from synthetic chemicals. And among these plant snbstances there will perhaps be some that do not have toxic or adverse side effects. [Pg.399]

A significant development underway is by Nobel laureate Tom Cech and coworkers at the University of Colorado. A protein designated POTl has been found to attach itself to the end of chromosomes and thereby keep telomerase away from the tips so that cancer cannot develop. Observed with mice, it is a long way to clinical confirmation in humans. (In comment, POTl can be called an inhibitor for telomerase.) [Pg.399]


Shi DF et al. (2001) Quadruplex-interactive agents as telomerase inhibitors synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J Med Chem 44(26) 4509-4523... [Pg.94]

Mergny JL et al. (2001) Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay. Proc Natl Acad Sci USA 98(6) 3062-3067... [Pg.95]

Shin-ya K et al. (2001) Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J Am Chem Soc 123(6) 1262-1263... [Pg.95]

Kim MY et al. (2002) Telomestatin, a potent telomerase inhibitor that interacts quite speciflcally with the human telomeric intramolecular g-quadruplex. J Am Chem Soc 124(10) 2098-2099... [Pg.95]

Quinoline Analogs as Antiangiogenic Agents and Telomerase Inhibitors... [Pg.329]

Damm K, Hemmann U, Garin Chesa P et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 2001 20 6958-6968. [Pg.170]

Tandem heterocycles are formed by posttranslational conversion of oligopeptide sequences consisted of serine, cysteine and threonine. A striking example of tandem heterocycles is telomestatin (Figure 7.2), a nanomolar telomerase inhibitor, which contains eight heterocycles. In its biosynthesis, five serines were converted to five oxazoles, two threonines to two methyloxazoles and one cysteine to one thiazoline [25]. [Pg.140]

Telomerase inhibitors are under development as potential anticancer agents. [Pg.158]

A photochemical approach has been used for the formation of the pyrrolocarbazole core of the telomerase inhibitor dictyodendrin B (Equation 81) <2005JA11620>, for the central core of furostifoline <2002CPB143> and for the synthesis of 7-azaindolocarbazoles <2002T6621>. [Pg.1171]

Scheme 6 Steps involved in the synthesis of bis-dimethylaminoethyl derivative, a novel human telomerase inhibitor, as reported by Caprio et al. (in 2000) [27]... Scheme 6 Steps involved in the synthesis of bis-dimethylaminoethyl derivative, a novel human telomerase inhibitor, as reported by Caprio et al. (in 2000) [27]...
Zhou and coworkers reported a new series of quindoline derivatives (1-10) that could be used to develop novel and potent telomerase inhibitors [31]. The structure of quindoline is shown in Fig. 3. [Pg.221]

The authors suggested that the quindoline derivatives might be potential lead compounds for the development of new telomerase inhibitors [26,31]. [Pg.222]

Khan MTH (2007) Quinoline Analogs as Antiangiogenic Agents and Telomerase Inhibitors. 11 213-229... [Pg.327]

Using Danishefsky s elegant fragment assembly (Lambert and Danishefsky 2006), 4a and 3 were joined to UCS1025A in just four further steps (Scheme 7), which now allows for a rapid generation of analogs, which supports our SAR-studies for this important telomerase inhibitor. [Pg.132]


See other pages where Telomerase inhibitor is mentioned: [Pg.75]    [Pg.77]    [Pg.166]    [Pg.161]    [Pg.145]    [Pg.36]    [Pg.166]    [Pg.167]    [Pg.115]    [Pg.142]    [Pg.86]    [Pg.118]    [Pg.213]    [Pg.219]    [Pg.220]    [Pg.130]    [Pg.126]    [Pg.126]    [Pg.136]    [Pg.137]    [Pg.138]    [Pg.351]   
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See also in sourсe #XX -- [ Pg.399 ]

See also in sourсe #XX -- [ Pg.154 ]

See also in sourсe #XX -- [ Pg.198 ]




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