Quadruplex repair

Lee YJ, Park SJ, Ciccone SL, Kim CR, Lee SH (2006) An in vivo analysis of MMC-induced DNA damage and its repair. Carcinogenesis 27(3) 446-453 Loehrer PJ, Einhom LH (1984) Drugs five years later. Cisplatin. Ann Intern Med 100(5) 704-713 Li G, Widom J (2004) Nucleosomes facilitate their own invasion. Nat Struct Mol Biol 11 763-769 Liu W, Sun D, Hurley LH (2005) Binding of G-quadruplex interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaca cells. Nucleosides Nucleotides Nucleic Acids 24(10-12) 1801-1815... 

MutSot binds to G4 DNA with affinity even higher than for the best of its documented substrates in canonical mismatch repair (apparent = 1 nM). This raises the possibility that MutSa directs a pathway for G4 DNA removal. However, downstream factors in this pathway may very well be distinct from those that typically participate in mismatch repair, because binding to G4 DNA is not sensitive to addition of ATP. Interestingly, the RecQ family helicase BLM interacts with and is stimulated by MutSa. This raises the possibility that MutSa might stimulate G4 DNA unwinding, rather than excision of quadruplex structures. 

Dameria RR, Knickelbein KE, Kepchia D, Jackson A, Armitage BA, Eckert KA, Opresko PL. Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability. DNA Repair. 2010 9 1119-29. 

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