The Role of Cations in Determining Quadruplex Structure and Stability

The Role of Cations in Determining Quadruplex Structure and Stability 

Owing to their physiological importance, K and Na ions are the most extensively characterized cations with respect to their ability to stabilize G-quadruplex structures. However, a number of other cations are also known to promote G-quadruplex formation. The list of cations thus far includes the monovalent cations Rb, Cs, and Tl, as well as the divalent 

2 Crystallographic Analysis of Cation Coordination within G-Quadruplexes 

The X-ray crystal structure at 1.86 A resolution of the Oxytricha nova telomere end binding protein (OnTEBP) in complex with DNA and in the presence of NaCl (PDB ID 1JB7) has also shown that d(G4T4G4) adopts a 

A crystal structure has also been determined, at 2.1 A resolution, for the monomolecular G-quadruplex formed by d[AGGG(TTAGGG)3] in the presence of ions (PDB ID IKFl). Similar to the crystal structures described 

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