Structural Diversity of G-Quadruplex Scaffolds

Considered together, these four studies ably demonstrate the ability of DCC to rapidly yield lead structures for interesting targets. Despite the relatively small size of the libraries examined in each case, the diversity of structures accessible by the methodology is remarkable. G-quadruplex RNA has also been described [17], and therefore it is likely that future discovery efforts will also expand to targeting these sequences. Finally, as we will discuss later, G-quartets have served as scaffolds for the generation of novel materials via dynamic methods. 

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