Small Molecules that Interact with G-quadruplexes

4 Small Molecules that Interact with G-quadruplexes 

1 Small Molecules Stack on the Terminal G-tetrads of a G-quadruplex to Stabilize its Structure 

Many other small molecules are reported to stack with G-quadruplexes and have recently been reviewed in detail. Similarly, metal complexes with planar ligands also like to bind to G-quaduplexes via end-stacking. A typical example is Mn porphyrin complexes, which exhibited both high affinity and excellent selectivity for G-quadruplexes. This is possibly contributed by the metal ions, which are necessary for G-quadruplex stabilization. 

3 Small Molecules Bind to the Grooves/Loops/Backbone of a G-Quadruplex to Stabilize its Structure 

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