2- Propano

A mixture of 4,4 parts of 1-chloro-3-(1-naphthoxy)-2-propano and 16 parts of isopropylamine is heated in a sealed vessel at 70° B0°C for 10 hours. The vessel is cooled and to the contents there are added 50 parts of water. The mixture is acidified with 2N hydrochloric acid, and washed with 50 parts of ether. The aqueous phase Is decolorized with carbon, and then added to 50 parts of 2N sodium hydroxide solution at 0°C, The mixture is filtered. The solid residue is washed with water, dried, and crystallized from cyclohexane. There is thus obtained 1-isopropylamino-3-(1-naphthoxy)-2-propanol, MP 96°C. 

Bromomethyl)-lithium in the Preparation of Oxiranes Ethyl 2-Methyloxirane-2-propanoate. 

Urocanic acid (2-propanoic acid 3-[lH-imidazol-4-yl] is located superficially in the stratum comeum. Metabolism of epidermal UCA does not occur in situ due to the absence of urocanase, resulting in the accumulation of UCA in the epidermis. Upon UV exposure, naturally occurring trans-UCA converts to the d.s-isomer, in a dose dependent manner, until the photostationary state is reached, when equal quantities of trans- and m-UCA are found in the skin.15 Based on an analysis of the action spectrum for UV-induced immune suppression, and the fact that no immune suppression was observed in mice whose stratum comeum was previously removed by tape stripping, De Fabo and Noonan suggested that urocanic acid was the photoreceptor for UV-induced immune suppression.16 Since the initial experiments many others have documented, the ability of ris-UCA to initiate immune suppression, documented its presence in the serum of UV-irradiated mice, and demonstrated that m-UCA plays a role in UV-induced skin cancer induction. (For a more complete review of the role of m-UCA in immune suppression see two excellent reviews by Norval and colleagues.1718)... 

Attractive Compounds. The female-produced sex pheromone of the yellow mealworm beetle, Tenebrio molitor, is (R)-4-methyl- 1-nonanol [316] 163 (Scheme 18). Careful investigations on the biosynthesis of this compound [317] revealed that it is produced through a modification of normal fatty acid biosynthesis (Fig. 1, Fig. 2) propanoate serves as the starter, while formal chain elongation with acetate, propanoate, and acetate (accompanied by removal of the oxygens) produces 4-methylnonanoate which yields the pheromone alcohol after reduction. The structures and role of proteins that are present in the hemolymph or secreted by the tubular accessory glands of T. molitor, and that may carry lipophilic chemical messengers (like pheromones) are under investigation [318,319]. 

Fig. 9.4.26 Optical absorption spectra of Au-UFP/2-propano suspension as a function of time. The numbers in the figure are the passage of time after the preparation of the sample. The. sample colloids were prepared by a gas flow-solution trap method. (Front Ref. 27.)...

A 3,15-disubstituted heptahelicene (35) was prepared as the starting compound for two products which possess a bridge connecting the terminal rings 3,15-ethano-and 3,15-(oxa-2 -propano)heptaheIicene 20> (37 and 38),... 

In the second step of H2 addition, the reduction of the 3-keto-group, a strong effect of the donor molecule on the stereochemistry was observed moving from 2-propano, to 2-octanol. However, an excess of the equatorial alcohol was obtained in every case. 

A variety of important drugs contain the chiral substituent 2-propanoic acid, e. g., naproxen, for which the patent has now expired. Using the methodology of enantioselective hydrogenation, the corresponding a-substituted acrylic acids give high optical inductions [69]. However, in most cases the tedious synthesis of the acrylic acid precursor is the obstacle to industrial application (cf. Sections 2.9 and 3.3.1). 

The aim and purpose of the synthesis of tin(II) heterobimetallic derivatives is to prepare such a material that could deliver both elements of a final material simultaneously, leading to formation of complex ceramic materials in a single step, and was envisaged in the deposition of SrTa206 directly from [SrTa2(OEt)6(/u.-OEt)4(/u.-bis-dmap)2] , where dmap = l,3-bis(dimethylamino)-2-propanoate. 

Barr-David, R, and Dodge, B. R, 1959. Vapor liquid equilibrium at high pressures, the systems ethanol -f water and 2-propano -f water. J. Chem. Eng. Data, 4 107-121. 

Reggio PH, Wang T, Brown AE, Fleming DN, Seltzman HH, Griffin G, Pertwee RG, Compton DR, Abood ME, Martin BR (1997) Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity synthesis and characterization of a series of O,2-propano-delta-8-tetrahydrocannabinol analogs. J Med Chem 40 3312-3318... 

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