2- Formyl-3- propanoate

Ethyl 3-[4-(Ethoxycarbonylmethyl)-2-fluoro-5-formyl-l//-pyrrol-3-yl propanoate (5) Typical Procedure ... 

PyrroIe-1-propanoic acid, p-ethyl-2-formyl- 4249, 4573a ... 

H-Pyrrole-1-acetic acid, 2-formyl-a,5-dimethyl-1H-Pyrrole-1-acetic acid, 2-formyl-a-hexyl-1H-Pyrrole-1-acetic acid, 2-formyl-a-methyl-1H-Pyrrole-1-butanoic acid, 2-formyl-1H-Pyrrole-1-butanoic acid, 2-formyl-y-methyl-1H-Pyrrole-1-butanoic acid, 2-formyl-5-methyl-1H-Pyrrole-1-hexanoic acid, 2-formyl-1H-Pyrrole-1-octanoic acid, 2-formyl-1H-Pyrrole-1-octanoic acid, 2-formyl-5-methyl-1H-Pyrrole-1-propanoic acid, p-ethyl-2-formyl-1H-Pyrrole-1-propanoic acid, 2-formyl-p-methyl-... 

The pyrimidine rings of 970 were built on the 2-formyl-3-()8-D-ribofurano-syl)propanoate enol ether derivative 969 by reaction with urea, thiourea, or guanidine (79MI2, 79TL3669 83BCJ2700) (Scheme 279). 

Reactions with Radicals. Isoquinoline does react with radicals to give addition to the 1-position with subsequent loss of hydrogen. The Minisci reaction is a well-known example of this transformation. It is an effective reaction for the addition of hydroxymethyl, alkyl, and acyl radicals. Formyl and carbamoyl groups have also be added using this method. Acidic conditions help to promote the reaction. Alkylation is effective when carried out with alkyl iodides or alkyl xanthates. Hydroxymethyla-tion can also be carried out. Photochemical-induced free radical reactions have also been reported. Alkylation is possible using ethanol or propanoic acid but low yields are often obtained. Addition of a phenyl group can be achieved in 81% yield. ... 

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