Polycyclic carcinogen

Ahokas, J.T., Pelkonen, 0. and K rki, N.T. The possible role of trout liver aryl hydrocarbon hydroxylase in activating aromatic polycyclic carcinogens. In Jollow, D.J. Kocsis, J.J., Snyder, R. and Vainio, H. (Eds.) Biological Reactive Intermediates. Formation, Toxicity, and inactivation (1977) Plenum Press, New York, pp 162-166. 

STRUCTURAL SIMILARITY BETWEEN SOME ANTINEOPLASTIC AGENTS AND POLYCYCLIC CARCINOGENIC HYDROCARBONS 37... 

In this connection, crystal structures of the (+) - trans-anti-1 i a P D E- N2-dG adduct in the Y-family lesion bypass DNA polymerase IV (Dpo4) (see also Chapter 15 by Chandani and Loechler) from the archaeon Sulfolobus solfataricus reveal that the favored P domain is preserved in the enzyme in this case [51], Overall, a survey of crystal structures of DNA damaged by polycyclic carcinogenic chemicals shows that structures observed in DNA duplexes in solution by high-resolution NMR methods are often observed in polymerases [37] however, the preferred P domain can be overridden by strong lesion-polymerase interactions, as was manifested in a crystal structure of a B[a]PDE-derived adenine lesion [52],... 

H. Brune, and J. Misfeld Inventory and biological impact of polycyclic carcinogens in the environment Exp. Path. 24 (1983) 3-13. 

Many people absorb nicotine into their bodies as a result of smoking or chewing tobacco. In small doses, nicotine behaves like a stimulant and is not especially harmful. However, it is habit-forming, and habitual tobacco users are exposed to other harmful substances such as tars, carbon monoxide, and polycyclic carcinogens. 

During the preparation of this manuscript, the sad news was received that Professor Nguyen Phue Buu-Hdi had died, only shortly after the death of Professor Antoine Lacassagne. Prince Buu-Hoi was a remarkable man, distinguished in several fields, but especially so in the structure and activity of polycyclic carcinogens [209, 210]. While his death is an irreplaceable loss to the international cancer research community, his life and his immense contribution to the literature will surely prove an inspiration in the future. 

Coombs, M. M., Castegnaro, M. Low catalytic oxidation of polycyclic carcinogens, in The Disposal of Hazardous Waste from Laboratories, p. 31, London, The Royal Society of Chemistry, 1983... 

Klibenzanthracene, C22H 4. Crystallizes in silvery leaflets, m.p. 262 C. A polycyclic aromatic carcinogen obtained from coal tar. The 7,8 derivative, m.p. 196, is also known. 

A large number of polycyclic aromatic hydrocarbons are known Many have been synthesized m the laboratory and several of the others are products of com bustion Benzo[a]pyrene for example is present m tobacco smoke contaminates food cooked on barbecue grills and collects m the soot of chimneys Benzo[a]pyrene is a carcinogen (a cancer causing substance) It is converted m the liver to an epoxy diol that can induce mutations leading to the uncontrolled growth of certain cells... 

Carcinogens Cancer-producing agents Skin Respiratory Bladder/urinary tract Liver Nasal Bone marrow Coal tar pitch dust crude anthracene dust mineral oil mist arsenic. Asbestos polycyclic aromatic hydrocarbons nickel ore arsenic bis-(chloromethyl) ether mustard gas. p-naphthylamine benzidine 4-am i nodi pheny lam ine. Vinyl chloride monomer. Mustard gas nickel ore. Benzene. 

Polycyclic aromatic hydrocarbons have been classified as human carcinogens because they induce cancers in experimental animals and because smoking and exposure to mixtures of chemicals containing polycyclic aromatic hydrocarbons in the workplace increase the risk of lung cancer in exposed individuals. In experimental animals, benzo(a)pyrene induces cancer in different organs depending on the route of administration.Furthermore, exposure to polycyclic aromatic hydrocarbons commonly occurs in occupations related to traffic (use of diesel engines in transportation and railways). 

Another interesting, but rather complex system, which couples flow injection analysis, EC and GC has been recently reported (47). This system allows the determination of the total amount of potentially carcinogenic polycyclic aromatic compounds (PACs) in bitumen and bitumen fumes. This system could also be used for the analysis of specific PACs in other residual products. 

Dihydro-9,10-epoxyphenanthrene and related arene oxides are of considerable interest as carcinogens formed by polycyclic aromatic hydrocarbons in vivo.45 Phenanthrene oxide does not isomerize to the corresponding dibenzoxepin under thermal conditions. Photolysis of... 

Benzo[a]pyrene, a molecule with five, fused, hexagonal rings, is among the most carcinogenic of the polycyclic aromatic hydrocarbons (PAHs). Such biological activity may be related to the electronic structure of benzo[a]pyrene and its metabolites. Ionization energies of these molecules therefore have been investigated with photoelectron spectroscopy [28]. 

WATTENBERG L w (1977) Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compormds , J Nat Cancer Inst, 58 395-8. 

Mahaffey WR, DT Gibson, CE Cerniglia (1988) Bacterial oxidation of chemical carcinogens formation of polycyclic aromatic acids from benz[a]anthracene. Appl Environ Microbiol 54 2415-2423. 

---