Carcinogenicity of polycyclic hydrocarbons

Grover PL, Sims P, Mitchley BCU, et al. 1975. The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice. Br J Cancer 31 182-188. 

Calcium channel blocking drugs, 24 (1987) 249 Cannabinoid drugs, 24 (1987) 159 Carcinogenicity of polycyclic hydrocarbons, 10 (1974) 159... 

WATTENBERG L w (1977) Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compormds , J Nat Cancer Inst, 58 395-8. 

R. G. Harvey, The Molecular Mechanism of Carcinogenesis of Polycyclic Hydrocarbons , in Molecular Mechanisms of Carcinogenicity and Antitumor Activity , Eds. C. Chagas, B. Pullman, Pontifica Academia Scientiarum, The Vatican, and Adenine Press, Schenectady, NY, 1987, p. 95 - 129. 

JECFA (2005) used this approach to evaluate the carcinogenicity of polycyclic aromatic hydrocarbons (PAH), acrylamide, and ethyl carbamate in food. 

When studying the carcinogenic activity of polycyclic hydrocarbons and their antdogs containing thiophene rings (cf. Tilak "), Tilak et al synthesized both thienothiophene 1 and its isomer 2 in low yield from 2-thienyl dimethoxyethyl sulfide (23) and 3-thienyl diethoxyethyl sulfide (24), respectively, by the method developed for synthesis of thiophenes and thiopyrans - [Eqs. (10) and (11)]. The compounds 23 and 24 were prepared from 2- and 3-mercaptothiophenes. ... 

The K-region theory has been replaced by the theory of bay-region activation of polycyclic hydrocarbons to give mutagens and carcinogens.208 A... 

Wattenberg LW. 1972. Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin. J Natl Cancer Inst 48 1425-1430. 

Wattenberg, L.W. Inhibition of carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Antioxidants and Ethoxyquin. J. Natl Cancer Inst, 48 1425-1430, 1972. 

Norden, B., Edlund, U., and Wold, S., Carcinogenicity of polycyclic aromatic hydrocarbons, studied by SIMCA pattern recognition, Acta Chemica Scandinavica Series B, 32, 602-608, 1978. 

The Pullmans were the first to use electronic structure calculations in several studies on the carcinogenicity of polycyclic aromatic hydrocarbons and hetero analogs in the late 1940s and early 1950s. Much of the early work on... 

G. Klopman, K. Namboodiri, and A. N. Kalos, in Molecular Basis of Cancer, Part A Macromolecular Structure, Carcinogens and Oncogenes, R. Rein, Ed., Alan R. Liss, 1985, pp. 287—298. Computer Automated Evaluation and Prediction of the Iball Index of Carcinogenicity of Polycyclic Aromatic Hydrocarbons. 

S. N. Mohammad, Indian J. Biochem. Biophys., 22, 56 (1985). MINDO/3 Calculations of Carcinogenic Activities of Polycyclic Hydrocarbons. 

Villemin, D., Cherqaoui, D. and Mesbah, A. (1994). Predicting Carcinogenicity of Polycyclic Aromatic Hydrocarbons from Backpropagation Neural Network. J.Chem.lnf.Comput.Sci., 34, 1288-1293. 

Ville.min D, Cherqaoui D, Mesbah A. Predicting carcinogenicity of polycyclic aromatic hydrocarbons from back-propagation neural network. J Chem Inf Comput Sci 1994 34 1288-93. 

Biological activation of polycyclic-hydrocarbon carcinogens proceeds through dihydrodiols and diol epoxides and such pathways are clearly possible for aza-aromatic compounds. To assist in investigating the existence of such routes, a range of dihydrodiols and diol epoxides of benz[c]acridine and benz[a]acridine (R.E. Lehr and S. Kumar, J. org. Chem., 1981, 367 ... 

Bulay OM, Wattenberg LW. 1971. Carcinogenic effects of polycyclic hydrocarbon carcinogen administration to mice during pregnancy on the progeny. J Natl Cancer Inst 46 397-402. 

S.S. Epstein (1963). The photodynamic activity of polycyclic hydrocarbons carcinogens. Acta Unio Int. Cancrum, 19, 599-601. 

Straif, K., Baan, R., Grosse, Y., Secretan, B., El Ghissassi, E., and Cogliano, V. (2005). Carcinogenicity of polycyclic aromatic hydrocarbons. Lancet Oncol 6, 931-932. 

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