Carcinogens polycyclic aromatic

Another interesting, but rather complex system, which couples flow injection analysis, EC and GC has been recently reported (47). This system allows the determination of the total amount of potentially carcinogenic polycyclic aromatic compounds (PACs) in bitumen and bitumen fumes. This system could also be used for the analysis of specific PACs in other residual products. 

Metabolites of carcinogenic polycyclic aromatic hydrocarbons (PAH) such as ( ) trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahy-drobenzo[a]pyrene (BPDE) and 7,8,9,10-tetrahydroxytetrahydroben-zo[ a] pyrene (BPT) participate in tt binding interactions with nucleotide bases (1-19) which lead to the reversible formation of... 

Grimmer, G. (ed.). 1983. Environmental Carcinogens Polycyclic Aromatic Hydrocarbons. Chemistry, Occurrence, Biochemistry, Carcinogenicity. CRC Press, Boca Raton, FL. 261 pp. 

Tong C, Fazio M, Williams GM. 1981. Rat hepatocyte-mediated mutagenesis of human cells by carcinogenic polycyclic aromatic hydrocarbons but not organochlorine pesticides. Proc Soc Exp Biol Med 167(4) 572-575. 

Fig. 5 Typical deformations detected in 96 hpf zebrafish embryos exposed at the indicated concentrations of the carcinogenic polycyclic aromatic hydrocarbons Benzo[a]Pyrene (b) and Benazo [k]Fluoranthene (c), or to the reportedly nontoxic AhR-ligand (3-naphthofiavone (d). A nonexposed, normal specimen is shown in (a). Arrows indicate (a) pericardial edema, (b) malformation of the lower jaw, (c) malformation of the tail, (tf) color of the yolk, and (e) coagulation...

Use of Response/Effect Addition in the Risk Assessment of Mixtures OF Carcinogenic Polycyclic Aromatic Hydrocarbons... 

Schmahl, D., R. P. Deutsch-Wenzel, H. Brune, P. Schneider, U. Mohr, M. Habs, F. Pott, and D. Steinhoff, Biological Activity, in Environmental Carcinogens Polycyclic Aromatic Hydrocarbons (G. Grimmer, Ed.), pp. 157-220, CRC Press, Boca Raton, FL, 1983. 

James N. Pitts, Jr., is a Research Chemist at the University of California, Irvine, and Professor Emeritus from the University of California, Riverside. He was Professor of Chemistry (1954-1988) and cofounder (1961) and Director of the Statewide Air Pollution Research Center (1970-1988) at the University of California, Riverside. His research has focused on the spectroscopy, kinetics, mechanisms, and photochemistry of species involved in a variety of homogeneous and heterogeneous atmospheric reactions, including those associated with the formation and fate of mutagenic and carcinogenic polycyclic aromatic compounds. He is the author or coauthor of more than 300 research publications and three books Atmospheric Chemistry Fundamentals and Experimental Techniques, Graduate School in the Sciences—Entrance, Survival and Careers, and Photochemistry. He has been coeditor of two series, Advances in Environmental Science and Technology and Advances in Photochemistry. He served on a number of panels in California, the United States, and internationally. These included several National Academy of Science panels and service as Chair of the State of California s Scientific Review Panel for Toxic Air Contaminants and as a member of the Scientific Advisory Committee on Acid Deposition. 

Initially, particular attention was focused on the epoxides of the so-called K region. As in the case of benzo [a] pyrene and certain other polycyclic aromatic hydrocarbons, these were more carcinogenic than the parent compound. The K region had attracted particular interest, as it is electronically the most reactive portion of the polycyclic aromatic hydrocarbon molecule. However, with other carcinogenic polycyclic aromatic hydrocarbons, this was not found to be the case. It now seems that the ultimate carcinogen is an epoxide of a dihydrodiol metabolite, where the epoxide is adjacent to the so-called bay region (Fig. 7.2). 

Carcinogenic polycyclic aromatic hydrocarbons can contaminate smoked food (Bartle, 1991), although the main dietary sources of these compounds in the UK appear to be early in food production. 

GRIMMER G (eds) Environmental Carcinogens Polycyclic Aromatic Hydrocarbons, CRC Press, Boca Raton, 1983. 

One of the most potent carcinogenic polycyclic aromatic hydrocarbons. In animals, large single and multiple doses produce tumors of the skin, breast, and stomach or leukemias, regardless of route of administration. It is a strong mutagen after metabolic activation.2-4... 

H. Yu, Environmental carcinogenic polycyclic aromatic hydrocarbons Photochemistry and phototoxicity. J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev. C20, 149-183... 

Dickhut, R.M., Canuel, E.A., Gustafson, K.E., Liu, K., Arzayus, K.M., Walker, S.E., Edgecombe, G., Gaylor, M.O., and Macdonald, E.H. (2000) Automotive sources of carcinogenic polycyclic aromatic hydrocarbons associated with particulate matter in the Chesapeake bay region. Environ. Sci. Technol. 34, 4635-4640. 

S. M. Adams and L. S. Kaminsky, Mol. Pharmacol., 22, 459 (1982). Molecular Orbital Studies of Epoxide Stability of Carcinogenic Polycyclic Aromatic Hydrocarbon Diol Epoxides. 

Garcia, C., Gonzalez, V, Cornejo, C., Palma-Fleming, H., and Lagos N., 2004. First evidence of dinophysistoxin-1 ester and carcinogenic polycyclic aromatic hydrocarbons in smoked bivalves collected in the Patagonia fjords. Toxicon, 43(2), 121-131. 

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