Polychlorinated biphenyls changes

Polychlorinated biphenyls (PCBs) zero 0.0005 Skin changes thymus gland problems immune deficiencies reproductive or nervous system difficulties increased risk of cancer Runoff from landfils discharge of waste chemicals... 

Eby, L.A., C.A. Stow, R.J. Hesselberg, and J.F. Kitchell. 1997. Modeling changes in growth and diet on polychlorinated biphenyl accumulation in Coregonus hoyi. Ecol. Appl. 7 981-990. 

Rifkind, A.B., A. Firpo, Jr., and D.R. Alonso. 1984. Coordinate induction of cytochrome P-448 mediated mixed function oxidases and histopathologic changes produced acutely in chick embryo liver by polychlorinated biphenyl congeners. Toxicol. Appl. Pharmacol. 72 343-354. 

Schantz, S.L., B.W. Seo, J. Moshtaghian, and S. Amin. 1997. Developmental exposure to polychlorinated biphenyls of dioxin do changes in thyroid function mediated effects on spatial learning Amer. Zool. 37 399-408. 

Figure 22. Log-log plot of equilibrium weight change of homogeneous nonbonded protective garment material following immersion in a polychlorinated biphenyl...

Kim, B.-H., Ikonomou, M.G., Lee, S.-J., Kim, H.-S., Chang, Y.-S., 2005e. Concentrations of polybrominated diphenyl ethers, polychlorinated dibenzo-p-dioxins and dibenzofu-rans, and polychlorinated biphenyls in human blood samples from Korea. Sci. Total Environ. 336, 45-56. 

Guo YL, Lin CJ, Yao WJ, et al. 1994. Musculoskeletal changes in children prenatally exposed to polychlorinated biphenyls and related compounds (Yu-Cheng children). J Toxicol Environ Health 41 83-93. 

Noren K. 1988. Changes in the levels of organochlorine pesticides, polychlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans in human milk from Stockholm, Sweden 1972-1985. Chemosphere 17 39-50. 

Intermediate-duration oral studies in rats have shown that high doses of DEHP can affect thyroid cell structure (e g., hypertrophy of Golgi apparatus, increases in lysosomes, dilation of the endoplasmic reticula, and increase in colloid droplets) and function (e.g., decrease levels of circulating T4) (Hinton et al. 1986 Poon et al. 1997 Price et al. 1987, 1988a). When large oral doses of 500 and 2,500 mg/kg/day DEHP were combined with dietary exposure to a compound which has similar effects on the thyroid (Aroclor 1254, a polychlorinated biphenyl mixture), there was an apparent additive effect of the two compounds on changes in thyroid cell structure and decreases in serum T3 and T4. At lower doses of DEHP (50 and 100 mg/kg/day) and Aroclor 1254 there were no additive effects apparent with the changes in cell structure or the levels of T3 and T4. 

Alcock, R. E., Johnston, A. E., et al (1993) Long-term changes in the polychlorinated biphenyl content of United Kingdom soils. Environmental Science and Technology, 27(9) 1918-1923. 

Chen, C.-Y., J.T. Hamm, J.R. Hass, P.W. Albro and L.S. Bimbaum. A mixture of polychlorinated dibenzo-/i-dioxms (PCDDs), dibenzofurans (PCDFs), and non-ortho polychlorinated biphenyls (PCBs) changed the lipid content of pregnant Long Evans rats. Chemosphere 46 1501 — 1504, 2002. 

The reactivity, fate, and distribution of bound solutes are certainly changed by association with stream humic substances. The rate of photolysis of certain organic compounds (Zepp et al., 1981a,b), the rate of volatilization of polychlorinated biphenyls (Griffin and Chian, 1980), the bioaccumulation of polynuclear aromatic hydrocarbons in fish (Leversee, 1981), the rate of humic acid induced acid-base catalysis (Perdue, 1983), and the rate of microbiological decomposition are some specific examples. The octyl ester of 2,4-D (2,4 DOE) was predicted by theoretical and mathematical models and found by experimentation to be resistant to base hydrolysis when bound to humic substances (Perdue, 1983). The same model predicted the humic acid catalyzed hydrolysis of atrazine as demonstrated by Li and Felbeck 11972). 

I I. A farming couple in Northern Michigan consult their physician about severe skin rashes and ulcers noted over the past year. They also have lost many cattle over the past year, and claim that their cattle feed changed in consistency and smell about 1 year ago. Chemical analysis of the feed shows high concentrations of polychlorinated biphenyls, a fertilizer related to known carcinogens. The physician sends the chemical to a laboratory for carcinogen testing, which is performed initially and rapidly by... 

The chemical is banned. Prohibited for importation, formulation, manufacturing and final disposal in the national territory of the substances polychlorinated biphenyls, pentachlorofenol, crocidolite, polybrominated biphenols, polychlorinated terphenyls and tris (2,3-dibFomopropyl) phosphate on the basis that they cause environmental pollution and have toxic effects against human health. All uses are banned. Liver changes. 

Allen JR, Abrahamson LJ. 1973. Morphological and biochemical changes in the liver of rats fed polychlorinated biphenyls. Arch Environ Contam Toxicol 1 265-280. 

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